CB-002

Modify Date: 2023-01-15 11:43:05

CB-002 Structure
CB-002 structure
Common Name CB-002
CAS Number 61034-15-9 Molecular Weight 271.27500
Density N/A Boiling Point N/A
Molecular Formula C13H13N5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CB-002


CB-002 is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts; increases expression of endogenous p53 target genes NOXA, DR5, and p21 and cell death; decreases the stability of mutant p53 in RXF393 cancer cells and an exogenously expressed R175H p53 mutant in HCT116 p53-null cells.

 Names

Name 8-anilino-1,3-dimethyl-7H-purine-2,6-dione
Synonym More Synonyms

 Chemical & Physical Properties

Molecular Formula C13H13N5O2
Molecular Weight 271.27500
Exact Mass 271.10700
PSA 87.94000
LogP 0.12580

 Synonyms

8-Anilino-1,3-dimethyl-3,7-dihydro-purin-2,6-dion
8-Phenylaminotheophyllin
8-anilino-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
8-Anilino-1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione
8-phenylaminotheophylline
8-anilino-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
1H-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-8-(phenylamino)
8-anilino-1,3-dimethyl-3,7(9)-dihydro-purine-2,6-dione
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