61034-15-9

61034-15-9 structure

Name: CB-002
Chemical Name: 8-anilino-1,3-dimethyl-7H-purine-2,6-dione
CAS Number: 61034-15-9
Molecular Formula: C₁₃H₁₃N₅O₂
Molecular Weight: 271.27500
Create Date: 2017-08-24 08:41:10
Modify Date: 2025-08-22 19:30:05
CB-002 is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts; increases expression of endogenous p53 target genes NOXA, DR5, and p21 and cell death; decreases the stability of mutant p53 in RXF393 cancer cells and an exogenously expressed R175H p53 mutant in HCT116 p53-null cells.

Name	8-anilino-1,3-dimethyl-7H-purine-2,6-dione
Synonyms	8-Anilino-1,3-dimethyl-3,7-dihydro-purin-2,6-dion 8-Phenylaminotheophyllin 8-anilino-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione 8-Anilino-1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione 8-phenylaminotheophylline 8-anilino-1,3-dimethyl-3,7-dihydro-purine-2,6-dione 1H-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-8-(phenylamino) 8-anilino-1,3-dimethyl-3,7(9)-dihydro-purine-2,6-dione