61034-15-9
61034-15-9 structure
- Name: CB-002
- Chemical Name: 8-anilino-1,3-dimethyl-7H-purine-2,6-dione
- CAS Number: 61034-15-9
- Molecular Formula: C13H13N5O2
- Molecular Weight: 271.27500
- Create Date: 2017-08-24 08:41:10
- Modify Date: 2023-01-15 11:43:05
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CB-002 is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts; increases expression of endogenous p53 target genes NOXA, DR5, and p21 and cell death; decreases the stability of mutant p53 in RXF393 cancer cells and an exogenously expressed R175H p53 mutant in HCT116 p53-null cells.
| Name | 8-anilino-1,3-dimethyl-7H-purine-2,6-dione |
|---|---|
| Synonyms |
8-Anilino-1,3-dimethyl-3,7-dihydro-purin-2,6-dion
8-Phenylaminotheophyllin 8-anilino-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione 8-Anilino-1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione 8-phenylaminotheophylline 8-anilino-1,3-dimethyl-3,7-dihydro-purine-2,6-dione 1H-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-8-(phenylamino) 8-anilino-1,3-dimethyl-3,7(9)-dihydro-purine-2,6-dione |
| Molecular Formula | C13H13N5O2 |
|---|---|
| Molecular Weight | 271.27500 |
| Exact Mass | 271.10700 |
| PSA | 87.94000 |
| LogP | 0.12580 |