β-Naphthoflavone

Modify Date: 2024-01-06 18:13:38

β-Naphthoflavone structure	Common Name	β-Naphthoflavone
	CAS Number	6051-87-2	Molecular Weight	272.30
	Density	1.3±0.1 g/cm3	Boiling Point	460.9±45.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₁₂O₂	Melting Point	185-189 °C
	MSDS	USA	Flash Point	215.8±22.3 °C
	Symbol	GHS07	Signal Word	Warning

Use of β-Naphthoflavone

β-Naphthoflavone is a non-carcinogenic AhR agonist as a positive control for the induction of AhR transcriptional activity[1]. β-Naphthoflavone inhibits hydrogen peroxide-induced apoptosis[2].

Name	β-naphthoflavone
Synonym	More Synonyms

Description	β-Naphthoflavone is a non-carcinogenic AhR agonist as a positive control for the induction of AhR transcriptional activity[1]. β-Naphthoflavone inhibits hydrogen peroxide-induced apoptosis[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor Research Areas >> Neurological Disease
References	[1]. Ishida T, Takechi S. β-Naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor, disrupts zinc homeostasis in human hepatoma HepG2 cells. J Toxicol Sci. 2019;44(10):711-720. [2]. Zhu Y, et al. α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage. Exp Ther Med. 2017 Mar;13(3):1143-1150.

Description

β-Naphthoflavone is a non-carcinogenic AhR agonist as a positive control for the induction of AhR transcriptional activity[1]. β-Naphthoflavone inhibits hydrogen peroxide-induced apoptosis[2].

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor

Research Areas >> Neurological Disease

References

[1]. Ishida T, Takechi S. β-Naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor, disrupts zinc homeostasis in human hepatoma HepG2 cells. J Toxicol Sci. 2019;44(10):711-720.

[2]. Zhu Y, et al. α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage. Exp Ther Med. 2017 Mar;13(3):1143-1150.

Density	1.3±0.1 g/cm3
Boiling Point	460.9±45.0 °C at 760 mmHg
Melting Point	185-189 °C
Molecular Formula	C₁₉H₁₂O₂
Molecular Weight	272.30
Flash Point	215.8±22.3 °C
Exact Mass	272.083740
PSA	30.21000
LogP	4.79
Appearance of Characters	yellow to tan
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.695
Storage condition	2-8°C

β-Naphthoflavone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL6200000

CHEMICAL NAME :: 1H-Naphtho(2,1-b)pyran-1-one, 3-phenyl-

CAS REGISTRY NUMBER :: 6051-87-2

BEILSTEIN REFERENCE NO. :: 0018991

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H12-O2

MOLECULAR WEIGHT :: 272.31

WISWESSER LINE NOTATION :: T B666 CV FOJ ER

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03239 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 450 mg/kg/3D-I

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Metabolism (Intermediary) - other proteins

REFERENCE :: HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 11,580,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 600 mg/kg/4D-I

TOXIC EFFECTS :: Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 15,93,1985 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 120 mg/kg

SEX/DURATION :: female 8-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 24,1,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 80 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 7,159,1987

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn,Xi,C,F
Risk Phrases	22-34-11
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	QL6200000
HS Code	2914399090

Precursor 10
CAS#:40649-77-2 3-phenyl-1-(2'-... CAS#:1219684-05-5 1-(2-tert-butyl... CAS#:58483-57-1 1-(1'-Hydroxyna... CAS#:109-01-3 methylpiperazine
CAS#:1219684-00-0 1-(2-tert-butyl... CAS#:2860-03-9 BETA-NAPHTHOFLA... CAS#:100-52-7 Benzaldehyde CAS#:574-19-6 1-(2-hydroxy-1-...
CAS#:93-97-0 Benzoic anhydride CAS#:94-02-0 Ethyl 3-oxo-3-p...
DownStream 0

HS Code	2914399090
Summary	2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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3-phenylbenzo[f]chromen-1-one

1H-Naphtho[2,1-b]pyran-1-one, 3-phenyl-

MFCD00064288

EINECS 227-958-4

b-Naphthoflavone

BIDD:ER0570

3-Phenyl-1H-benzo[f]chromen-1-one

β-Naphthoflavone

5,6-Benzoflavone

b-NF

beta-naphthoflavone

DC Chemicals Limited
China
Product Name: beta-Naphthoflavone
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5,6-Benzoflavone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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