Arecaidine hydrochloride

Modify Date: 2025-08-27 13:01:49

Arecaidine hydrochloride structure	Common Name	Arecaidine hydrochloride
	CAS Number	6018-28-6	Molecular Weight	177.62900
	Density	N/A	Boiling Point	266.7ºC at 760 mmHg
	Molecular Formula	C₇H₁₂ClNO₂	Melting Point	260ºC
	MSDS	N/A	Flash Point	115.1ºC

Use of Arecaidine hydrochloride

Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].

Name	Arecaidine hydrochloride
Synonym	More Synonyms

Description	Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
References	[1]. D Lodge, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22. [2]. Valerie Voigt, et al. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). J Pharm Pharmacol. 2013 Apr;65(4):582-90.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

References

[1]. D Lodge, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22.

[2]. Valerie Voigt, et al. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). J Pharm Pharmacol. 2013 Apr;65(4):582-90.

Boiling Point	266.7ºC at 760 mmHg
Melting Point	260ºC
Molecular Formula	C₇H₁₂ClNO₂
Molecular Weight	177.62900
Flash Point	115.1ºC
Exact Mass	177.05600
PSA	40.54000
LogP	1.07280
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT2087000

CHEMICAL NAME :: Nicotinic acid, 1,2,5,6-tetrahydro-1-methyl-, hydrochloride

CAS REGISTRY NUMBER :: 6018-28-6

LAST UPDATED :: 199007

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H11-N-O2.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year: 113,123,1969

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
WGK Germany	3
RTECS	QT2087000
HS Code	2933399090

3-Pyridinecarbo...

CAS#:61-94-9

~66%

Arecaidine hydr...

CAS#:6018-28-6

Literature: Martin, Arnold R.; Paradkar, Vidyadhar M.; Peng, Geoffrey W.; Speth, Robert C.; Yamamura, Henry I.; Horn, Alan S. Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 865 - 873

Arecoline hydro...

CAS#:300-08-3

Arecaidine hydr...

CAS#:6018-28-6

Literature: WO2013/184757 A1, ; Page/Page column 108 ;

Precursor 2
CAS#:61-94-9 3-Pyridinecarbo... CAS#:300-08-3 Arecoline hydro...
DownStream 1
CAS#:5657-70-5 1-methylpiperid...

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid,hydrochloride

MFCD00051993

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Arecaidine hydrochloride
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Arecaidine hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Get all suppliers and price by the below link:

Arecaidine hydrochloride suppliers

Arecaidine hydrochloride price

Arecaidine hydrochloride

Use of Arecaidine hydrochloride

Names