Orphan GPCR SP9155 agonist P550 (mouse, rat)

Modify Date: 2024-01-11 23:51:03

Orphan GPCR SP9155 agonist P550 (mouse, rat) Structure
Orphan GPCR SP9155 agonist P550 (mouse, rat) structure
Common Name Orphan GPCR SP9155 agonist P550 (mouse, rat)
CAS Number 600171-70-8 Molecular Weight 2820.122
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C126H195N37O37 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Orphan GPCR SP9155 agonist P550 (mouse, rat)


Orphan GPCR SP9155 agonist P550 (mouse, rat) (26RFa (mouse, rat)), a member of the RFamide peptide family with orexigenic effect, is the cognate ligand of the mouse orphan receptor GPR103, also designated SP9155 or AQ27[1][2].

 Names

Name L-Alanyl-L-serylglycyl-L-prolyl-L-leucylglycyl-L-threonyl-L-leucyl-L-alanyl-L-α-glutamyl-L-α-glutamyl-L-leucyl-L-seryl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-arginyl-L-lysylglycylglycyl-L-phenylalanyl-L-seryl-L-phenylalanyl-L-arginyl-L-phenylalaninamide
Synonym More Synonyms

  Biological Activity

Description Orphan GPCR SP9155 agonist P550 (mouse, rat) (26RFa (mouse, rat)), a member of the RFamide peptide family with orexigenic effect, is the cognate ligand of the mouse orphan receptor GPR103, also designated SP9155 or AQ27[1][2].
Related Catalog
In Vitro 26RFa is a key neuropeptide in the regulation of energy metabolism[2].
In Vivo 26RFa dose-dependently reduces glucose-induced insulin release, inhibits the insulin responses to both arginine and exendin-4 and did not affect glucagon output in rat pancreas[3].
References

[1]. Chartrel N, et al. Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc Natl Acad Sci U S A. 2003;100(25):15247-15252.

[2]. Chartrel N, et al. The Neuropeptide 26RFa (QRFP) and Its Role in the Regulation of Energy Homeostasis: A Mini-Review. Front Neurosci. 2016;10:549. Published 2016 Nov 29.

[3]. Egido EM, et al. 26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas. Peptides. 2007;28(4):725-730.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C126H195N37O37
Molecular Weight 2820.122
Exact Mass 2818.451416
LogP -5.87
Index of Refraction 1.664

 Synonyms

L-Alanyl-L-serylglycyl-L-prolyl-L-leucylglycyl-L-threonyl-L-leucyl-L-alanyl-L-α-glutamyl-L-α-glutamyl-L-leucyl-L-seryl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-arginyl-L-lysylglycylglycyl-L-pheny lalanyl-L-seryl-L-phenylalanyl-L-arginyl-L-phenylalaninamide
L-Phenylalaninamide, L-alanyl-L-serylglycyl-L-prolyl-L-leucylglycyl-L-threonyl-L-leucyl-L-alanyl-L-α-glutamyl-L-α-glutamyl-L-leucyl-L-seryl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-arginyl-L-lysy lglycylglycyl-L-phenylalanyl-L-seryl-L-phenylalanyl-L-arginyl-
Orphan GPCR SP9155 Agonist P550 (mouse) trifluoroacetate salt
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