Orphan GPCR SP9155 agonist P550 (mouse, rat)

Names

[ Name ]:
Orphan GPCR SP9155 agonist P550 (mouse, rat)

[Synonym ]:
L-Alanyl-L-serylglycyl-L-prolyl-L-leucylglycyl-L-threonyl-L-leucyl-L-alanyl-L-α-glutamyl-L-α-glutamyl-L-leucyl-L-seryl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-arginyl-L-lysylglycylglycyl-L-pheny lalanyl-L-seryl-L-phenylalanyl-L-arginyl-L-phenylalaninamide
L-Phenylalaninamide, L-alanyl-L-serylglycyl-L-prolyl-L-leucylglycyl-L-threonyl-L-leucyl-L-alanyl-L-α-glutamyl-L-α-glutamyl-L-leucyl-L-seryl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-arginyl-L-lysy lglycylglycyl-L-phenylalanyl-L-seryl-L-phenylalanyl-L-arginyl-
Orphan GPCR SP9155 Agonist P550 (mouse) trifluoroacetate salt

Biological Activity

[Description]:

Orphan GPCR SP9155 agonist P550 (mouse, rat) (26RFa (mouse, rat)), a member of the RFamide peptide family with orexigenic effect, is the cognate ligand of the mouse orphan receptor GPR103, also designated SP9155 or AQ27[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

26RFa is a key neuropeptide in the regulation of energy metabolism[2].

[In Vivo]

26RFa dose-dependently reduces glucose-induced insulin release, inhibits the insulin responses to both arginine and exendin-4 and did not affect glucagon output in rat pancreas[3].

[References]

[1]. Chartrel N, et al. Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc Natl Acad Sci U S A. 2003;100(25):15247-15252.

[2]. Chartrel N, et al. The Neuropeptide 26RFa (QRFP) and Its Role in the Regulation of Energy Homeostasis: A Mini-Review. Front Neurosci. 2016;10:549. Published 2016 Nov 29.

[3]. Egido EM, et al. 26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas. Peptides. 2007;28(4):725-730.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₁₂₆H₁₉₅N₃₇O₃₇

[ Molecular Weight ]:
2820.122

[ Exact Mass ]:
2818.451416

[ LogP ]:
-5.87

[ Index of Refraction ]:
1.664

Related Compounds

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