(Ala13)-Apelin-13 (human, bovine, mouse, rat) acetate salt

Names

[ Name ]:
(Ala13)-Apelin-13 (human, bovine, mouse, rat) acetate salt

[Synonym ]:
qrprlshkgpmpa
GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA
(Ala13)-Apelin-13 (human, bovine, mouse, rat)

Biological Activity

[Description]:

(Ala13)-Apelin-13 is a potent apelin receptors (APJ) antagonist. (Ala13)-Apelin-13 inhibits gastric motility through vagal cholinergic pathway[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[In Vivo]

(Ala13)-Apelin-13 (1-300 pmol/60 nl；显微注射到 DVC 中) 以剂量依赖性方式降低大鼠的胃张力和胃动力[1]。 Animal Model: 250-300 g, Sprague-Dawley rats[1] Dosage: 1-300 pmol/60 nl Administration: Microinjected into the DVC (dorsal vagal complex (DVC) Result: Decreased gastric tone and motility in a dose-dependent manner with D50 ≈ 27 pmol for both antrum and corpus.

[References]

[1]. Bülbül M, et al. Apelin-13 inhibits gastric motility through vagal cholinergic pathway in rats. Am J Physiol Gastrointest Liver Physiol. 2018 Feb 1;314(2):G201-G210.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₃H₁₀₇N₂₃O₁₆S

[ Molecular Weight ]:
1474.73000

[ Exact Mass ]:
1473.80000

[ PSA ]:
653.27000

[ LogP ]:
0.87870

[ Storage condition ]:
-20°C