ranimustine

Modify Date: 2024-01-08 18:29:31

ranimustine structure	Common Name	ranimustine
	CAS Number	58994-96-0	Molecular Weight	327.71900
	Density	1.69 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₀H₁₈ClN₃O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ranimustine

Ranimustine (MCNU) is a nitrosourea alkylating agent, can be used for research of chronic myelogenous leukemia and polycythemia vera[1][3][4].

Name	Ranimustine
Synonym	More Synonyms

Description	Ranimustine (MCNU) is a nitrosourea alkylating agent, can be used for research of chronic myelogenous leukemia and polycythemia vera[1][3][4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker
In Vivo	Ranimustine reduces spermidine and spermine in the corpus striatum, and spermine in the diencephalon, but increases putrescine in the corpus striatum and combined thalamus and hypothalamus[2].

Density	1.69 g/cm3
Molecular Formula	C₁₀H₁₈ClN₃O₇
Molecular Weight	327.71900
Exact Mass	327.08300
PSA	140.92000
Index of Refraction	1.616

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ5910000

CHEMICAL NAME :: Glucopyranoside, methyl-6-((((2-chloroethyl)nitrosoamino)carbonyl)amin o)-6-deoxy-, alpha-D-

CAS REGISTRY NUMBER :: 58994-96-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C10-H18-Cl-N3-O7

MOLECULAR WEIGHT :: 327.76

WISWESSER LINE NOTATION :: T6OTJ BO1 CQ DQ EQ F1MVNNO&2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 46400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 31800 ug/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 45700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41200 ug/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 5 mg/kg

SEX/DURATION :: female 5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: AMKUDT Acta Medica Kinki University. (Kinki Univ. Medical Assoc., 380 Nishiyama, Sayama-cho, Minami-kawachi-gun, Osaka-fu, Japan) V.1- 1976- Volume(issue)/page/year: 11,57,1986

Hazard Codes	T
Risk Phrases	R25:Toxic if swallowed. R41:Risk of serious damage to eyes. R43:May cause sensitization by skin contact.
Safety Phrases	S26-S36/37/39-S45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	XU7700000
Packaging Group	III
Hazard Class	6.1

1-(2-chloroethy...

CAS#:58994-95-9

~42%

ranimustine

CAS#:58994-96-0

Literature: Sosnovsky; Rao Journal of Pharmaceutical Sciences, 1991 , vol. 80, # 7 p. 693 - 699

METHYL-6-DEOXY-...

CAS#:5155-43-1

ranimustine

CAS#:58994-96-0

Literature: Sosnovsky; Rao Journal of Pharmaceutical Sciences, 1991 , vol. 80, # 7 p. 693 - 699

Precursor 2
CAS#:58994-95-9 1-(2-chloroethy... CAS#:5155-43-1 METHYL-6-DEOXY-...
DownStream 0

Cymerin

MCNU

MFCD00866369

Thymerin

RCL L16,919-6

1-(2-chloroethyl)-1-nitroso-3-[[(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-methoxy-oxan-2-yl]methyl]urea

Ranomustine

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ranimustine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: ranimustine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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ranimustine

Use of ranimustine

Names

ranimustine Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

Synonyms