ranimustine

Names

[ Name ]:
ranimustine

[Synonym ]:
Cymerin
MCNU
MFCD00866369
Thymerin
RCL L16,919-6
1-(2-chloroethyl)-1-nitroso-3-[[(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-methoxy-oxan-2-yl]methyl]urea
Ranomustine

Biological Activity

[Description]:

Ranimustine (MCNU) is a nitrosourea alkylating agent, can be used for research of chronic myelogenous leukemia and polycythemia vera[1][3][4].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker

[In Vivo]

Ranimustine reduces spermidine and spermine in the corpus striatum, and spermine in the diencephalon, but increases putrescine in the corpus striatum and combined thalamus and hypothalamus[2].

Chemical & Physical Properties

[ Density]:
1.69 g/cm3

[ Molecular Formula ]:
C₁₀H₁₈ClN₃O₇

[ Molecular Weight ]:
327.71900

[ Exact Mass ]:
327.08300

[ PSA ]:
140.92000

[ Index of Refraction ]:
1.616

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ5910000

CHEMICAL NAME :: Glucopyranoside, methyl-6-((((2-chloroethyl)nitrosoamino)carbonyl)amin o)-6-deoxy-, alpha-D-

CAS REGISTRY NUMBER :: 58994-96-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C10-H18-Cl-N3-O7

MOLECULAR WEIGHT :: 327.76

WISWESSER LINE NOTATION :: T6OTJ BO1 CQ DQ EQ F1MVNNO&2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 46400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 31800 ug/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 45700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41200 ug/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 5 mg/kg

SEX/DURATION :: female 5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: AMKUDT Acta Medica Kinki University. (Kinki Univ. Medical Assoc., 380 Nishiyama, Sayama-cho, Minami-kawachi-gun, Osaka-fu, Japan) V.1- 1976- Volume(issue)/page/year: 11,57,1986

Safety Information

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R25:Toxic if swallowed. R41:Risk of serious damage to eyes. R43:May cause sensitization by skin contact.

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
XU7700000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.