DSRM-3716

Modify Date: 2024-01-06 19:41:55

DSRM-3716 structure	Common Name	DSRM-3716
	CAS Number	58142-99-7	Molecular Weight	255.06
	Density	1.8±0.1 g/cm3	Boiling Point	336.8±15.0 °C at 760 mmHg
	Molecular Formula	C₉H₆IN	Melting Point	N/A
	MSDS	N/A	Flash Point	157.5±20.4 °C

Use of DSRM-3716

DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection[1].

Name	5-Iodoisoquinoline
Synonym	More Synonyms

Description	DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: 75 nM (SARM1 NADase)[1]
In Vitro	DSRM-3716 treatment produces dose-dependent inhibition of cADPR increase (IC50 of 2.8 μM) and substantial preservation of NAD+ in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells[1]. DSRM-3716 prevents neurofilament light chain (NfL) release from severed axons in a dose-dependent manner, with an IC50 of ~2 μM[1]. The potency of DSRM-3716 to inhibit cADPR increase caused by axotomy (IC50 of 2.8 μM) is similar to the potency required to prevent axonal degeneration (IC50 of 2.1 μM)[1]. DSRM-3716 inhibits the SARM1-dependent cell destruction pathway triggered by Rotenone in sensory neurons[1].
References	[1]. Robert O Hughes, et al. Small Molecule SARM1 Inhibitors Recapitulate the SARM1 -/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate. Cell Rep. 2021 Jan 5;34(1):108588.

Density	1.8±0.1 g/cm3
Boiling Point	336.8±15.0 °C at 760 mmHg
Molecular Formula	C₉H₆IN
Molecular Weight	255.06
Flash Point	157.5±20.4 °C
Exact Mass	254.954483
PSA	12.89000
LogP	2.99
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.724
Storage condition	2-8°C

Hazard Codes	Xi

Isoquinolin-5-amine

CAS#:1125-60-6

~78%

DSRM-3716

CAS#:58142-99-7

Literature: Gamage, Swarna A.; Spicer, Julie A.; Rewcastle, Gordon W.; Milton, John; Sohal, Sukhjit; Dangerfield, Wendy; Mistry, Prakash; Vicker, Nigel; Charlton, Peter A.; Denny, William A. Journal of Medicinal Chemistry, 2002 , vol. 45, # 3 p. 740 - 743

5-Bromoisoquinoline

CAS#:34784-04-8

~77%

DSRM-3716

CAS#:58142-99-7

Literature: Hamad Elgazwy, Abdel-Sattar S. Phosphorus, Sulfur and Silicon and Related Elements, 2000 , vol. 164, p. 131 - 143

Isoquinoline

CAS#:119-65-3

DSRM-3716

CAS#:58142-99-7

Literature: Hamad Elgazwy, Abdel-Sattar S. Phosphorus, Sulfur and Silicon and Related Elements, 2000 , vol. 164, p. 131 - 143

Precursor 3
CAS#:1125-60-6 Isoquinolin-5-amine CAS#:34784-04-8 5-Bromoisoquinoline CAS#:119-65-3 Isoquinoline
DownStream 3
CAS#:23687-27-6 8-Aminoisoquinoline CAS#:856832-08-1 3-iodophthalimide CAS#:6937-34-4 3-Iodophthalic acid