- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: DSRM-3716
- Price: ￥1558.0/1g ￥648.0/250mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 5-IODOISOQUINOLINE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Isoquinoline, 5-iodo- (9CI)
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
58142-99-7
58142-99-7 structure
- Name: DSRM-3716
- Chemical Name: 5-Iodoisoquinoline
- CAS Number: 58142-99-7
- Molecular Formula: C9H6IN
- Molecular Weight: 255.06
- Catalog: Research Areas Neurological Disease
- Create Date: 2018-05-22 08:00:00
- Modify Date: 2024-01-06 19:41:55
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DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection[1].
| Name | 5-Iodoisoquinoline |
|---|---|
| Synonyms |
5-Iodoisoquinoline
Isoquinoline, 5-iodo- Isoquinoline,5-iodo 5-iodo-isoquinoline 5-Jod-isochinolin |
| Description | DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 75 nM (SARM1 NADase)[1] |
| In Vitro | DSRM-3716 treatment produces dose-dependent inhibition of cADPR increase (IC50 of 2.8 μM) and substantial preservation of NAD+ in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells[1]. DSRM-3716 prevents neurofilament light chain (NfL) release from severed axons in a dose-dependent manner, with an IC50 of ~2 μM[1]. The potency of DSRM-3716 to inhibit cADPR increase caused by axotomy (IC50 of 2.8 μM) is similar to the potency required to prevent axonal degeneration (IC50 of 2.1 μM)[1]. DSRM-3716 inhibits the SARM1-dependent cell destruction pathway triggered by Rotenone in sensory neurons[1]. |
| References |
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 336.8±15.0 °C at 760 mmHg |
| Molecular Formula | C9H6IN |
| Molecular Weight | 255.06 |
| Flash Point | 157.5±20.4 °C |
| Exact Mass | 254.954483 |
| PSA | 12.89000 |
| LogP | 2.99 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.724 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi |
|---|
|
~78%
58142-99-7 |
| Literature: Gamage, Swarna A.; Spicer, Julie A.; Rewcastle, Gordon W.; Milton, John; Sohal, Sukhjit; Dangerfield, Wendy; Mistry, Prakash; Vicker, Nigel; Charlton, Peter A.; Denny, William A. Journal of Medicinal Chemistry, 2002 , vol. 45, # 3 p. 740 - 743 |
|
~77%
58142-99-7 |
| Literature: Hamad Elgazwy, Abdel-Sattar S. Phosphorus, Sulfur and Silicon and Related Elements, 2000 , vol. 164, p. 131 - 143 |
|
~%
58142-99-7 |
| Literature: Hamad Elgazwy, Abdel-Sattar S. Phosphorus, Sulfur and Silicon and Related Elements, 2000 , vol. 164, p. 131 - 143 |
| Precursor 3 | |
|---|---|
| DownStream 3 | |
