p38 MAP Kinase Inhibitor III

Modify Date: 2024-01-11 13:05:08

p38 MAP Kinase Inhibitor III structure	Common Name	p38 MAP Kinase Inhibitor III
	CAS Number	581098-48-8	Molecular Weight	404.503
	Density	1.3±0.1 g/cm3	Boiling Point	589.4±60.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₂₁FN₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	310.2±32.9 °C

Use of p38 MAP Kinase Inhibitor III

p38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an 50 of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with 50 values of 0.37 μM and 0.044 μM, respectively[1].

Name	(S)-p38 MAP Kinase Inhibitor III
Synonym	More Synonyms

Description	p38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an 50 of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with 50 values of 0.37 μM and 0.044 μM, respectively[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology
Target	p38 MAP kinase:0.9 μM (IC50)
References	[1]. Stefan A Laufer, et al. Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44.

Density	1.3±0.1 g/cm3
Boiling Point	589.4±60.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₁FN₄S
Molecular Weight	404.503
Flash Point	310.2±32.9 °C
Exact Mass	404.147095
LogP	4.78
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.675

(S)-p38 MAPK Inhibitor III

2-Pyridinamine, 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-

4-[5-(4-Fluorophenyl)-2-(methylsulfanyl)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-2-pyridinamine

p38 MAP Kinase Inhibitor III

Use of p38 MAP Kinase Inhibitor III

Names

p38 MAP Kinase Inhibitor III Biological Activity

Chemical & Physical Properties

Synonyms