TBBz
TBBz structure
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Common Name | TBBz | ||
|---|---|---|---|---|
| CAS Number | 577779-57-8 | Molecular Weight | 433.72000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C7H2Br4N2 | Melting Point | 330-332ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of TBBz4,5,6,7-Tetrabromobenzimidazole is a selective and ATP competitive CK2 (casein kinase 2) inhibitor[1]. |
| Name | 4,5,6,7-Tetrabromo-1H-benzimidazole |
|---|---|
| Synonym | More Synonyms |
| Description | 4,5,6,7-Tetrabromobenzimidazole is a selective and ATP competitive CK2 (casein kinase 2) inhibitor[1]. |
|---|---|
| Related Catalog | |
| Target |
CK2 |
| References |
| Melting Point | 330-332ºC |
|---|---|
| Molecular Formula | C7H2Br4N2 |
| Molecular Weight | 433.72000 |
| Exact Mass | 429.69500 |
| PSA | 28.68000 |
| LogP | 4.61290 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H319 |
| Precautionary Statements | P301 + P310-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| RIDADR | UN 2811 6.1 / PGIII |
| Precursor 1 | |
|---|---|
| DownStream 0 | |
CAS#:51-17-2|
An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets.
Mol. Cell. Proteomics 7(6) , 1077-88, (2008) Recently protein kinases have emerged as some of the most promising drug targets; and therefore, pharmaceutical strategies have been developed to inhibit kinases in the treatment of a variety of disea... |
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Casein kinase II contributes to the synergistic effects of BMP7 and BDNF on Smad 1/5/8 phosphorylation in septal neurons under hypoglycemic stress.
J. Neurochem. 109(3) , 733-43, (2009) The combination of bone morphogenetic protein 7 (BMP7) and neurotrophins (e.g. brain-derived neurotrophic factor, BDNF) protects septal neurons during hypoglycemic stress. We investigated the signalin... |
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Characterizing the convergence of protein kinase CK2 and caspase-3 reveals isoform-specific phosphorylation of caspase-3 by CK2α': implications for pathological roles of CK2 in promoting cancer cell survival.
Oncotarget 4 , 560-71, (2013) Protein kinase CK2 has emerged as a promising candidate for the treatment of a number of cancers. This enzyme is comprised of two catalytic subunits (CK2 and/or CK2α') that form complexes with homodim... |
| 4,5,6,7-Tetrabrom-1H-benzimidazol |
| 4,5,6,7-tetrabromobenzimidazole |
| 2oxy |
| TBBz |