U 44069

Modify Date: 2025-08-25 18:32:47

U 44069 structure	Common Name	U 44069
	CAS Number	56985-32-1	Molecular Weight	350.49
	Density	1.1±0.1 g/cm3	Boiling Point	519.7±35.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₃₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	176.1±19.4 °C
	Symbol	GHS02, GHS07	Signal Word	Danger

Use of U 44069

U-44069 is a stable prostaglandin (PG) H2 analogue and a potent vasoconstrictor. U-44069 induces Ca influx at preglomerular vessels[1].

Name	9,11-Dideoxy-9α,11α-epoxymethanoprostaglandin F2α
Synonym	More Synonyms

Description	U-44069 is a stable prostaglandin (PG) H2 analogue and a potent vasoconstrictor. U-44069 induces Ca influx at preglomerular vessels[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
References	[1]. Simpson AW, et, al. Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i. FEBS Lett. 1986 Jun 9;201(2):301-5. [2]. Loutzenhiser R, et, al. Reversal of renal and smooth muscle actions of the thromboxane mimetic U-44069 by diltiazem. Am J Physiol. 1986 Apr;250(4 Pt 2):F619-26.

Description

U-44069 is a stable prostaglandin (PG) H2 analogue and a potent vasoconstrictor. U-44069 induces Ca influx at preglomerular vessels[1].

Related Catalog

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

References

[1]. Simpson AW, et, al. Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i. FEBS Lett. 1986 Jun 9;201(2):301-5.

[2]. Loutzenhiser R, et, al. Reversal of renal and smooth muscle actions of the thromboxane mimetic U-44069 by diltiazem. Am J Physiol. 1986 Apr;250(4 Pt 2):F619-26.

Density	1.1±0.1 g/cm3
Boiling Point	519.7±35.0 °C at 760 mmHg
Molecular Formula	C₂₁H₃₄O₄
Molecular Weight	350.49
Flash Point	176.1±19.4 °C
Exact Mass	350.245697
PSA	66.76000
LogP	3.88
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.548

U 44069 MSDS(Chinese)

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H319-H336
Supplemental HS	Repeated exposure may cause skin dryness or cracking.
Precautionary Statements	P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn
Risk Phrases	20/21/22
Safety Phrases	22-36
RIDADR	UN1231 - class 3 - PG 2 - Methyl acetate, solution

Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice.

Prostaglandins Leukot. Essent. Fatty Acids 76(5) , 299-308, (2007)

The role of endothelin, PAF and thromboxane A2 in airway hyperreactivity (AHR) to carbachol induced by ovalbumin sensitization and challenge in Balb/c mice was investigated. Ovalbumin sensitization an...

Glibenclamide inhibits agonist-induced vasoconstriction of placental chorionic plate arteries.

Placenta 27(6-7) , 660-8, (2006)

Preliminary data suggest that K(ATP) channels may be expressed in placental arteries and veins [Wareing M, Turner C, Greenwood SL, Baker PN, Fyfe GK. Expression of mRNA encoding K+ channels in chorion...

Substrate binding is the rate-limiting step in thromboxane synthase catalysis.

J. Biol. Chem. 276(18) , 14737-43, (2001)

Thromboxane synthase (TXAS) is a "non-classical" cytochrome P450. Without any need for an external electron donor, or for a reductase or molecular oxygen, it uses prostaglandin H2 (PGH2) to catalyze e...

5-Heptenoic acid, 7-[(1S,4R,5S,6R)-5-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2-oxabicyclo[2.2.1]hept-6-yl]-, (5Z)-

(Z)-7-[(1R,2S,3R,4S)-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxabicyclo[2.2.1]heptan-3-yl]hept-5-enoic acid

(5Z)-7-{(1S,4R,5S,6R)-5-[(1E,3S)-3-Hydroxy-1-octen-1-yl]-2-oxabicyclo[2.2.1]hept-6-yl}-5-heptenoic acid

MFCD00135237

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: U-44069
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: U 44069
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.