Formestane

Modify Date: 2024-01-02 23:31:25

Formestane structure	Common Name	Formestane
	CAS Number	566-48-3	Molecular Weight	302.408
	Density	1.2±0.1 g/cm3	Boiling Point	475.4±45.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₂₆O₃	Melting Point	199-202°C
	MSDS	Chinese USA	Flash Point	255.4±25.2 °C
	Symbol	GHS08	Signal Word	Danger

Name	formestane
Synonym	More Synonyms

Density	1.2±0.1 g/cm3
Boiling Point	475.4±45.0 °C at 760 mmHg
Melting Point	199-202°C
Molecular Formula	C₁₉H₂₆O₃
Molecular Weight	302.408
Flash Point	255.4±25.2 °C
Exact Mass	302.188202
PSA	54.37000
LogP	2.66
Vapour Pressure	0.0±2.7 mmHg at 25°C
Index of Refraction	1.570
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8152500

CHEMICAL NAME :: Androst-4-ene-3,17-dione, 4-hydroxy-

CAS REGISTRY NUMBER :: 566-48-3

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H26-O3

MOLECULAR WEIGHT :: 302.45

WISWESSER LINE NOTATION :: L E5 B666 FV OV MUTJ A1 E1 NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 182 mg/kg

SEX/DURATION :: female 3-5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

REFERENCE :: JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 118,93,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 136 mg/kg

SEX/DURATION :: female 2-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

REFERENCE :: JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 118,93,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 120 mg/kg

SEX/DURATION :: female 11-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

REFERENCE :: ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030, Tokyo International, Tokyo, Japan) V.1- 1954- Volume(issue)/page/year: 36,29,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 250 mg/kg

SEX/DURATION :: female 3-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 100,1684,1977

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R60
Safety Phrases	S53-S36/37/39-S45
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	BV8152500

Screening estrogenic activities of chemicals or mixtures in vivo using transgenic (cyp19a1b-GFP) zebrafish embryos.

PLoS ONE 7 , e36069, (2012)

The tg(cyp19a1b-GFP) transgenic zebrafish expresses GFP (green fluorescent protein) under the control of the cyp19a1b gene, encoding brain aromatase. This gene has two major characteristics: (i) it is...

Combined inhibitory effect of formestane and herceptin on a subpopulation of CD44+/CD24low breast cancer cells.

Cancer Sci. 101 , 1661-9, (2010)

In breast cancer, stromal cells surrounding cancer epithelial cells can influence phenotype by producing paracrine factors. Among many mediators of epithelial-stromal interactions, aromatase activity ...

The effects of aromatase inhibitors and selective estrogen receptor modulators on eye development in the zebrafish (Danio rerio).

Curr. Eye Res. 32(10) , 819-27, (2007)

It has been shown that the steroid hormone estrogen plays an important role in the development of the central nervous system. The purpose of these studies was to determine the effect of estrogen on ze...

Androst-4-ene-3,17-dione, 4-hydroxy-

4-Hydroxyandrost-4-ene-3,17-dione

4-Hydroxy-4-androstene-3,17-dione

Formestane

B,Aromatase inhibitor

Lentaron

4-androsten-4-ol-3,17-dione

4-Hydroxyandrostenedione

4-OH-A

MFCD00057814

(8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Formestane
Price: ￥568.0/5g ￥168.0/1g
Purity: 99.0%
Stocking Period: 3 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Formestane
Price: $300.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU CHEM- Formestane
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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