PluriSIn #2
Modify Date: 2025-08-26 19:36:09
PluriSIn #2 structure
|
Common Name | PluriSIn #2 | ||
|---|---|---|---|---|
| CAS Number | 56563-17-8 | Molecular Weight | 249.19800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H8FN3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PluriSIn #2PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1]. |
| Name | 1-phenylcarbamoyl-5-fluorouracil |
|---|---|
| Synonym | More Synonyms |
| Description | PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
topoisomerase II alpha |
| In Vitro | PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level[1]. A 24h exposure of PluriSIn #2 (20 µM) is sufficient to induce massive cell death in hPSCs, but doesn’t affect the viability of various other cell types derived from them[1]. Western Blot Analysis[1] Cell Line: B153 and HUES9 human pluripotent stem cells (hPSCs) Concentration: 20 µM Incubation Time: 12 hours Result: Reduced TOP2A expression at the protein level. |
| References |
| Molecular Formula | C11H8FN3O3 |
|---|---|
| Molecular Weight | 249.19800 |
| Exact Mass | 249.05500 |
| PSA | 83.96000 |
| LogP | 0.82890 |
| 5-Fluor-1-phenylcarbamoyl-uracil |
| 1-Phenylcarbamoyl-5-fluoruracil |
| 5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidine-1-carboxylic acid phenylamide |
| 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidine-1-carboxylic acid anilide |
| 5-fluoro-1-phenylcarbamoyluracil |