PluriSIn #2

Names

[ Name ]:
PluriSIn #2

[Synonym ]:
5-Fluor-1-phenylcarbamoyl-uracil
1-Phenylcarbamoyl-5-fluoruracil
5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidine-1-carboxylic acid phenylamide
5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidine-1-carboxylic acid anilide
5-fluoro-1-phenylcarbamoyluracil

Biological Activity

[Description]:

PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[Target]

topoisomerase II alpha

[In Vitro]

PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level[1]. A 24h exposure of PluriSIn #2 (20 µM) is sufficient to induce massive cell death in hPSCs, but doesn’t affect the viability of various other cell types derived from them[1]. Western Blot Analysis[1] Cell Line: B153 and HUES9 human pluripotent stem cells (hPSCs) Concentration: 20 µM Incubation Time: 12 hours Result: Reduced TOP2A expression at the protein level.

[References]

[1]. Uri Ben-David, et al. Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha. Stem Cells. 2015 Mar;33(3):1013-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₈FN₃O₃

[ Molecular Weight ]:
249.19800

[ Exact Mass ]:
249.05500

[ PSA ]:
83.96000

[ LogP ]:
0.82890

Related Compounds

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