Cystamine dihydrochloride structure
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Common Name | Cystamine dihydrochloride | ||
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CAS Number | 56-17-7 | Molecular Weight | 225.203 | |
Density | 1.172g/cm3 | Boiling Point | 264.8ºC at 760mmHg | |
Molecular Formula | C4H14Cl2N2S2 | Melting Point | 217-220 °C (dec.)(lit.) | |
MSDS | Chinese USA | Flash Point | N/A | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of Cystamine dihydrochlorideCystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) [1][2][3]. |
Name | Cystamine dihydrochloride |
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Synonym | More Synonyms |
Description | Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) [1][2][3]. |
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Related Catalog | |
Target |
Caspase 3:23.6 μM (IC50) |
In Vitro | Cystamine (dihydrochloride) has inhibition activity for caspase-3 with an IC50 value of 23.6 μM[1]. Cystamine (0-500 μM; 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner[1]. Cystamine (250 μM; 10 h) robustly increases the levels of glutathione[1]. Western Blot Analysis[1] Cell Line: Human neuroblastoma SH-SY5Y cells Concentration: 250, 500 μM Incubation Time: 0-16 h Result: Inhibited the MG132-mediated activation of caspase-3. Inhibited the H2O2-mediated activation of caspase-3. Inhibited caspase-3 activity in a tTG-independent manner. |
In Vivo | Cystamine (dihydrochloride) (oral, i.p.; 112, 225 mg/kg) reduces Tgase activity and GGEL levels, lessens the behavioral and neuropathological severity, and extends survival in R6/2 transgenic HD mice[2]. Animal Model: R6/2 transgenic HD mice[2] Dosage: 112, 225 mg/kg Administration: Intraperitoneal or oral, daily Result: Significantly extended survival, improved body weight and motor performance, delayed the neuropathological sequela and significantly altered the levels of Tgase activity and N(Sigma)-(gamma-L-glutamyl)-L-lysine (GGEL) levels. |
Density | 1.172g/cm3 |
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Boiling Point | 264.8ºC at 760mmHg |
Melting Point | 217-220 °C (dec.)(lit.) |
Molecular Formula | C4H14Cl2N2S2 |
Molecular Weight | 225.203 |
Exact Mass | 223.997543 |
PSA | 102.64000 |
LogP | 3.28980 |
Stability | Stable. Incompatible with strong oxidizing agents. |
Water Solubility | soluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xn:Harmful; |
Risk Phrases | R22;R36/37/38 |
Safety Phrases | S37/39-S26-S36/37/39 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | KR7260000 |
HS Code | 29309070 |
Precursor 1 | |
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DownStream 9 | |
HS Code | 29309070 |
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Ethanamine, 2,2'-dithiobis-, hydrochloride (1:2) |
CYSTAMINIUM DICHLORIDE |
aed |
cystaminedihcl |
OYSTAMINE DIHYDROCHLORIDE |
2,2'-dithiodiethanamine dihydrochloride |
2,2'-diaminodiethyl disulfide dihydrochloride |
CystamineHcl |
2,2'-Disulfanediyldiethanamine dihydrochloride |
2,2'-dithiodiethylamine dihydrocloride |
cystamine 2hcl |
usafcb-34 |
MFCD00012905 |
EINECS 200-260-7 |
2,2'-Dithiobis[ethylamine] dihydrochloride |
2,2'-diaminoethyl disulfide dihydrochloride |