4-Hydroxyoxyphenbutazone
Modify Date: 2025-08-26 14:20:18
4-Hydroxyoxyphenbutazone structure
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Common Name | 4-Hydroxyoxyphenbutazone | ||
|---|---|---|---|---|
| CAS Number | 55648-39-0 | Molecular Weight | 340.37 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H20N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 4-Hydroxyoxyphenbutazone4-Hydroxyoxyphenbutazone kills both replicating and nonreplicating (NR) Mycobacterium tuberculosis (Mtb), including Mtb resistant to standard drugs. 4-Hydroxyoxyphenbutazone is a potent inhibitor of cytokine production. 4-Hydroxyoxyphenbutazone is an immunosuppressive drug and has the potential for rheumatoid arthritis research[1][2]. |
| Name | 4-Hydroxyoxyphenbutazone |
|---|
| Description | 4-Hydroxyoxyphenbutazone kills both replicating and nonreplicating (NR) Mycobacterium tuberculosis (Mtb), including Mtb resistant to standard drugs. 4-Hydroxyoxyphenbutazone is a potent inhibitor of cytokine production. 4-Hydroxyoxyphenbutazone is an immunosuppressive drug and has the potential for rheumatoid arthritis research[1][2]. |
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| Related Catalog | |
| In Vitro | 4-Hydroxyoxyphenbutazone 在液体培养物中杀死 R Mtb，存在 0.5% BSA 时 MIC 为 100 μM，在较低 BSA 浓度下 MIC 为 25 μM。4-Hydroxyphenbutazone 的杀菌谱非常窄，对 Mycobacterium smegmatis 的活性较弱 (在缺乏 BSA 的 7H9 中 MIC 为 200 μM)。 4-Hydroxyoxyphenbutazone 对 E. coli 和 S. enterica 等无活性[1]。 4-Hydroxyoxyphenbutazone 有效抑制外周单核细胞 (PBMC) 中的单核因子以及 Th1 和 Th2 淋巴因子[2]。 |
| References |
| Molecular Formula | C19H20N2O4 |
|---|---|
| Molecular Weight | 340.37 |
| InChIKey | DPLOKDYHDJEJST-UHFFFAOYSA-N |
| SMILES | CCCCC1(O)C(=O)N(c2ccccc2)N(c2ccc(O)cc2)C1=O |