55648-39-0

55648-39-0 structure

Name: 4-Hydroxyoxyphenbutazone
Chemical Name: 4-Hydroxyoxyphenbutazone
CAS Number: 55648-39-0
Molecular Formula: C₁₉H₂₀N₂O₄
Molecular Weight: 340.37
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2023-04-04 18:26:33
Modify Date: 2024-04-05 17:22:35
4-Hydroxyoxyphenbutazone kills both replicating and nonreplicating (NR) Mycobacterium tuberculosis (Mtb), including Mtb resistant to standard drugs. 4-Hydroxyoxyphenbutazone is a potent inhibitor of cytokine production. 4-Hydroxyoxyphenbutazone is an immunosuppressive drug and has the potential for rheumatoid arthritis research[1][2].

Name	4-Hydroxyoxyphenbutazone

Description	4-Hydroxyoxyphenbutazone kills both replicating and nonreplicating (NR) Mycobacterium tuberculosis (Mtb), including Mtb resistant to standard drugs. 4-Hydroxyoxyphenbutazone is a potent inhibitor of cytokine production. 4-Hydroxyoxyphenbutazone is an immunosuppressive drug and has the potential for rheumatoid arthritis research[1][2].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	4-Hydroxyoxyphenbutazone 在液体培养物中杀死 R Mtb，存在 0.5% BSA 时 MIC 为 100 μM，在较低 BSA 浓度下 MIC 为 25 μM。4-Hydroxyphenbutazone 的杀菌谱非常窄，对 Mycobacterium smegmatis 的活性较弱 (在缺乏 BSA 的 7H9 中 MIC 为 200 μM)。 4-Hydroxyoxyphenbutazone 对 E. coli 和 S. enterica 等无活性[1]。 4-Hydroxyoxyphenbutazone 有效抑制外周单核细胞 (PBMC) 中的单核因子以及 Th1 和 Th2 淋巴因子[2]。
References	[1]. Ben Gold, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. [2]. Anja Ten Brinke, et al. 4-Hydroxy-oxyphenbutazone is a potent inhibitor of cytokine production. Eur Cytokine Netw. 2005 Jun;16(2):144-51.

Molecular Formula	C₁₉H₂₀N₂O₄
Molecular Weight	340.37