Iprindole

Modify Date: 2025-08-25 16:48:45

Iprindole Structure
Iprindole structure
 Common Name Iprindole
CAS Number 5560-72-5 Molecular Weight 284.43900
Density 1.04g/cm3 Boiling Point 435.4ºC at 760mmHg
Molecular Formula C19H28N2 Melting Point N/A
MSDS N/A Flash Point 217.1ºC

 Use of Iprindole


Iprindole, a tricyclic indole antidepressant, is a weak inhibitor of the uptake of noradrenaline and 5-HT[1].

 Names

Name 3-(6,7,8,9,10,11-hexahydrocycloocta[b]indol-5-yl)-N,N-dimethylpropan-1-amine
Synonym More Synonyms

 Iprindole Biological Activity

Description Iprindole, a tricyclic indole antidepressant, is a weak inhibitor of the uptake of noradrenaline and 5-HT[1].
Related Catalog
In Vivo Iprindole produces less than 50% inhibition of the uptake of noradrenaline as well as that of 5-HT at 100 mg/kg i .p..
References

[1]. M I Gluckman, et al. The pharmacology of iprindole, a new antidepressant. Psychopharmacologia. 1969;15(3):169-85.

 Chemical & Physical Properties

Density 1.04g/cm3
Boiling Point 435.4ºC at 760mmHg
Molecular Formula C19H28N2
Molecular Weight 284.43900
Flash Point 217.1ºC
Exact Mass 284.22500
PSA 8.17000
LogP 4.25200
Index of Refraction 1.573
InChIKey PLIGPBGDXASWPX-UHFFFAOYSA-N
SMILES CN(C)CCCn1c2c(c3ccccc31)CCCCCC2

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GY0350000
CHEMICAL NAME :
5H-Cyclooct(b)indole, 5-(3-(dimethylamino)propyl)-6,7,8,9,10,11-hexahydro-
CAS REGISTRY NUMBER :
5560-72-5
LAST UPDATED :
199712
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C19-H28-N2
MOLECULAR WEIGHT :
284.49
WISWESSER LINE NOTATION :
T B658 HN&&TJ H3N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
775 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
187 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,130,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
484 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
195 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,130,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01206

 Synonyms

Prondol
Iprindole
Galatur
Pramindole
WY-3263
Tertran
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