WAY-181187 hydrochloride

Modify Date: 2025-11-02 14:30:52

WAY-181187 hydrochloride Structure
WAY-181187 hydrochloride structure
 Common Name WAY-181187 hydrochloride
CAS Number 554403-08-6 Molecular Weight 417.33
Density N/A Boiling Point N/A
Molecular Formula C15H14Cl2N4O2S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of WAY-181187 hydrochloride


WAY-181187 (SAX-187) hydrochloride is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM[1]. WAY-181187 hydrochloride mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[2].

 Names

Name 2-[1-(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonylindol-3-yl]ethanamine,hydrochloride
Synonym More Synonyms

 WAY-181187 hydrochloride Biological Activity

Description WAY-181187 (SAX-187) hydrochloride is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM[1]. WAY-181187 hydrochloride mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[2].
Related Catalog
Target

5-HT6 Receptor:2.2 nM (Ki)

5-HT6 Receptor:6.6 nM (EC50)

References

[1]. Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35.  

[2]. Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14.  

 Chemical & Physical Properties

Molecular Formula C15H14Cl2N4O2S2
Molecular Weight 417.33
Exact Mass 415.99400
PSA 119.01000
LogP 5.32520
InChIKey YWNBHKWSECANPP-UHFFFAOYSA-N
SMILES Cl.NCCc1cn(S(=O)(=O)c2c(Cl)nc3sccn23)c2ccccc12

 Synonyms

unii-xgk56c5380
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Chemsrc provides WAY-181187 hydrochloride(CAS#:554403-08-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of WAY-181187 hydrochloride are included as well.>> amp version: WAY-181187 hydrochloride

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