WAY-181187 hydrochloride

Names

[ Name ]:
WAY-181187 hydrochloride

[Synonym ]:
unii-xgk56c5380

Biological Activity

[Description]:

WAY-181187 (SAX-187) hydrochloride is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM[1]. WAY-181187 hydrochloride mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT6 Receptor:2.2 nM (Ki)

5-HT6 Receptor:6.6 nM (EC50)

[References]

[1]. Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35.

[2]. Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₄Cl₂N₄O₂S₂

[ Molecular Weight ]:
417.33

[ Exact Mass ]:
415.99400

[ PSA ]:
119.01000

[ LogP ]:
5.32520

Related Compounds

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