Davercin

Modify Date: 2024-01-02 19:06:07

Davercin Structure
Davercin structure
Common Name Davercin
CAS Number 55224-05-0 Molecular Weight 759.92100
Density 1.22 g/cm3 Boiling Point 859.8ºC at 760 mmHg
Molecular Formula C38H65NO14 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Davercin


Erythromycin Cyclocarbonate, derivative of Erythromycin, which is active against Gram-positive and some Gram-negative microorganisms.

 Names

Name Davercin
Synonym More Synonyms

 Davercin Biological Activity

Description Erythromycin Cyclocarbonate, derivative of Erythromycin, which is active against Gram-positive and some Gram-negative microorganisms.
Related Catalog
Target

Antibacterial[1]

In Vitro Erythromycin is used in treatment of respiratory, gastrointestinal, and genital tract infections, as well as skin and soft tissue infections. Erythromycin, with its ten chiral centers and two sugar substituents (L-cladinose and D-desosamine), is a good starting point for numerous medicinal chemistry efforts for improvement of its biological profile (better activity, higher stability, and improved bioavailability) since the first generation of macrolides, which had low toxicity and good tolerability, are unstable in acidic media, had low toxicity and good tolerability[1].
References

[1]. Jelic D, et al. From Erythromycin to Azithromycin and New Potential Ribosome-Binding Antimicrobials. Antibiotics (Basel). 2016 Sep 1;5(3). pii: E29.

 Chemical & Physical Properties

Density 1.22 g/cm3
Boiling Point 859.8ºC at 760 mmHg
Molecular Formula C38H65NO14
Molecular Weight 759.92100
Exact Mass 759.44100
PSA 188.98000
LogP 2.96780
Index of Refraction 1.534
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KF4670000
CHEMICAL NAME :
Erythromycin, cyclic 11,12-carbonate
CAS REGISTRY NUMBER :
55224-05-0
LAST UPDATED :
199206
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C38-H65-N-O14
MOLECULAR WEIGHT :
760.04

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 31,241,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4050 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 31,241,1974

 Synthetic Route

~%

Davercin Structure

Davercin

CAS#:55224-05-0

Literature: WO2012/115256 A1, ; Page/Page column 240 ;

 Synonyms

Erythromycin Cyclocarbonate
CWE
Erythromycin Cyclocarbonate
Dravercin
Eritromicina A carbonato
Carbonato ciclico de eritromicina a
Cykliczny weglan erytromycyny a
Cykliczny weglan erytromycyny A [polish]
erythromycin A cyclic 11,12-carbonate
Eritromicina A carbonato [spanish]
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