9H-Purine,6-(ethylthio)-

Modify Date: 2024-01-05 07:55:04

9H-Purine,6-(ethylthio)- Structure
9H-Purine,6-(ethylthio)- structure
Common Name 9H-Purine,6-(ethylthio)-
CAS Number 5417-84-5 Molecular Weight 180.23000
Density 1.39g/cm3 Boiling Point 460.2ºC at 760mmHg
Molecular Formula C7H8N4S Melting Point N/A
MSDS Chinese USA Flash Point 232.1ºC
Symbol GHS08
GHS08
Signal Word Warning

 Names

Name 6-ethylsulfanyl-7H-purine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.39g/cm3
Boiling Point 460.2ºC at 760mmHg
Molecular Formula C7H8N4S
Molecular Weight 180.23000
Flash Point 232.1ºC
Exact Mass 180.04700
PSA 79.76000
LogP 1.46490
Index of Refraction 1.758

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UO8535000
CHEMICAL NAME :
Purine, 6-(ethylthio)-
CAS REGISTRY NUMBER :
5417-84-5
LAST UPDATED :
198502
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H8-N4-S
MOLECULAR WEIGHT :
180.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
164 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 71,618,1982

 Safety Information

Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H351
Precautionary Statements P281
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn
Risk Phrases 40
Safety Phrases 22-36
RIDADR UN 2811 6.1/PG 3
RTECS UO8535000
HS Code 2933990090

 Synthetic Route

~%

9H-Purine,6-(ethylthio)- Structure

9H-Purine,6-(et...

CAS#:5417-84-5

Literature: Journal of the American Chemical Society, , vol. 81, p. 1898,1901 Journal of the American Chemical Society, , vol. 78, p. 5097,5098 Journal of the American Chemical Society, , vol. 80, p. 6697

~%

9H-Purine,6-(ethylthio)- Structure

9H-Purine,6-(et...

CAS#:5417-84-5

Literature: Journal of the American Chemical Society, , vol. 80, p. 6265,6266,6268,6269,6270

~%

9H-Purine,6-(ethylthio)- Structure

9H-Purine,6-(et...

CAS#:5417-84-5

Literature: Journal of Organic Chemistry, , vol. 24, p. 259,260

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles3

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Overexpression of v-ski blocks the terminal differentiation of chicken erythroblasts, and in cooperation with v-sea causes transformation of these cells, indicating that c-ski may play a role in regul...

6-ethylmercaptopurine-mediated growth inhibition of HL-60 cells in vitro irrespective of purine salvage.

Cancer Chemother. Pharmacol. 25(3) , 189-94, (1989)

A variety of purine analogs inhibit the growth and induce the differentiation of human promyelocytic leukemia (HL-60) cells that lack the purine salvage enzyme hypoxanthine-guanine phosphoribosyltrans...

Differential effect of 6-ethylmercaptopurine on c-myc expression in wild-type and HGPRT-deficient HL-60 cells.

Cancer Chemother. Pharmacol. 27(3) , 171-7, (1990)

A variety of compounds inhibit the growth and induce differentiation of human promyelocytic leukemia (HL-60) cells. HL-60 subclones that lack the purine salvage enzyme hypoxanthine-guanine phosphoribo...

 Synonyms

6-Ethylmercaptopurine
QA 69
6-ETHYLTHIOPURINE
6-Ethyl MP