9H-Purine,6-(ethylthio)-
Names
[ CAS No. ]:
5417-84-5
[ Name ]:
9H-Purine,6-(ethylthio)-
[Synonym ]:
6-Ethylmercaptopurine
QA 69
6-ETHYLTHIOPURINE
6-Ethyl MP
Chemical & Physical Properties
[ Density]:
1.39g/cm3
[ Boiling Point ]:
460.2ºC at 760mmHg
[ Molecular Formula ]:
C7H8N4S
[ Molecular Weight ]:
180.23000
[ Flash Point ]:
232.1ºC
[ Exact Mass ]:
180.04700
[ PSA ]:
79.76000
[ LogP ]:
1.46490
[ Index of Refraction ]:
1.758
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UO8535000
- CHEMICAL NAME :
- Purine, 6-(ethylthio)-
- CAS REGISTRY NUMBER :
- 5417-84-5
- LAST UPDATED :
- 198502
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C7-H8-N4-S
- MOLECULAR WEIGHT :
- 180.25
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 164 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 71,618,1982
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H351
[ Precautionary Statements ]:
P281
[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
40
[ Safety Phrases ]:
22-36
[ RIDADR ]:
UN 2811 6.1/PG 3
[ RTECS ]:
UO8535000
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Oncogene 9(5) , 1407-16, (1994)
Overexpression of v-ski blocks the terminal differentiation of chicken erythroblasts, and in cooperation with v-sea causes transformation of these cells, indicating that c-ski may play a role in regul...
6-ethylmercaptopurine-mediated growth inhibition of HL-60 cells in vitro irrespective of purine salvage.Cancer Chemother. Pharmacol. 25(3) , 189-94, (1989)
A variety of purine analogs inhibit the growth and induce the differentiation of human promyelocytic leukemia (HL-60) cells that lack the purine salvage enzyme hypoxanthine-guanine phosphoribosyltrans...
Differential effect of 6-ethylmercaptopurine on c-myc expression in wild-type and HGPRT-deficient HL-60 cells.Cancer Chemother. Pharmacol. 27(3) , 171-7, (1990)
A variety of compounds inhibit the growth and induce differentiation of human promyelocytic leukemia (HL-60) cells. HL-60 subclones that lack the purine salvage enzyme hypoxanthine-guanine phosphoribo...