Desogestrel

Modify Date: 2024-01-02 17:40:53

Desogestrel structure	Common Name	Desogestrel
	CAS Number	54024-22-5	Molecular Weight	310.473
	Density	1.1±0.1 g/cm3	Boiling Point	428.3±45.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₃₀O	Melting Point	109-110ºC
	MSDS	Chinese USA	Flash Point	187.9±21.7 °C
	Symbol	GHS09	Signal Word	Warning

Use of Desogestrel

Desogestrel(Org-2969) is a third-generation 19-nortestosterone derivative progestogen; is contained in many oral contraceptive preparations, both combined (COCs) to ethinyl-estradiol (EE) or alone in a progestin-only pill (POP).

Name	desogestrel
Synonym	More Synonyms

Description	Desogestrel(Org-2969) is a third-generation 19-nortestosterone derivative progestogen; is contained in many oral contraceptive preparations, both combined (COCs) to ethinyl-estradiol (EE) or alone in a progestin-only pill (POP).
Related Catalog	Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Others
References	[1]. Gassen DT, et al. Evaluation of hormonal suppression with two contraceptive regimens using ethinyl estradiol and desogestrel. Arch Gynecol Obstet. 2013 Feb;287(2):289-94.

Density	1.1±0.1 g/cm3
Boiling Point	428.3±45.0 °C at 760 mmHg
Melting Point	109-110ºC
Molecular Formula	C₂₂H₃₀O
Molecular Weight	310.473
Flash Point	187.9±21.7 °C
Exact Mass	310.229675
PSA	20.23000
LogP	6.59
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.566
Storage condition	-20°C

Desogestrel MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JF7975000

CHEMICAL NAME :: 18,19-Dinorpregn-4-en-20-yn-17-ol, 13-ethyl-11-methylene-, (17-alpha)-

CAS REGISTRY NUMBER :: 54024-22-5

LAST UPDATED :: 198910

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C22-H30-O

MOLECULAR WEIGHT :: 310.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6 ug/kg

SEX/DURATION :: female 20 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 16,51,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 24 ug/kg

SEX/DURATION :: female 20 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - other measures of fertility

REFERENCE :: ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 83,429,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6300 ng/kg

SEX/DURATION :: female 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: EXMDA4 International Congress Series--Excerpta Medica. (Excerpta Medica, Inc., POB 3085, Princeton, NJ 08540) No.1- 1952- Volume(issue)/page/year: (396),252,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 28 mg/kg

SEX/DURATION :: male 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,231,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6250 ug/kg

SEX/DURATION :: female 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,231,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 125 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,231,1983

Symbol	GHS09
Signal Word	Warning
Hazard Statements	H410
Precautionary Statements	P273-P501
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	24/25
RIDADR	UN 3077 9 / PGIII
RTECS	JF7975000

Precursor 4
CAS#:54024-21-4 13-ethyl-11-met... CAS#:74-86-2 Acetylene CAS#:220332-82-1 (8S,9S,10R,14S)... CAS#:161640-05-7 17β-(tert-butyl...
DownStream 1
CAS#:54048-10-1 Etonogestrel

Changes in the size of rectovaginal endometriotic nodules infiltrating the rectum during hormonal therapies.

Arch. Gynecol. Obstet. 287(3) , 447-53, (2013)

To evaluate the changes in the volume of rectovaginal endometriotic nodules infiltrating the rectum during 12-month treatment with hormonal therapies.This prospective, non-randomized, self-controlled ...

The risk of venous thrombosis in women over 50 years old using oral contraception or postmenopausal hormone therapy.

J. Thromb. Haemost. 11(1) , 124-31, (2013)

Oral contraception (OC) and postmenopausal hormone therapy (HT) can be used to alleviate menopausal symptoms. However, the risk of venous thrombosis (VT) associated with OC use in women over 50 years ...

Progestogen-only contraceptive pill compared with combined oral contraceptive in the treatment of pain symptoms caused by endometriosis in patients with migraine without aura.

Eur. J. Obstet. Gynecol. Reprod. Biol. 179 , 63-8, (2014)

Evaluate patient satisfaction at 6-month treatment in women with symptomatic rectovaginal endometriosis and migraine without aura with (progestogen-only contraceptive pill, POP versus sequential combi...

(8S,9S,10R,13S,14S,17R)-13-éthyl-17-éthynyl-11-méthylidène-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tétradécahydro-1H-cyclopenta[a]phénanthrén-17-ol

Desogestrel

(8S,9S,10R,13S,14S,17R)-17-Ethinyl-13-ethyl-11-methyliden-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol

(17α)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol

DESOGESTRAL

13-Ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-17-ol

17a-Ethynyl-18-methyl-11-methyl-ene-D4-estren-17b-ol

(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylidene-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol (non-preferred name)

13-ethyl-11-methylene-18,19-dinor-17a-pregn-4-en-20-yn-17-ol

org2969

(17a)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol

Marvelon 150/320

Cerazette

(8S,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-11-methylene-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol

Dicromil

(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylidene-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol

Cyclosa

DC Chemicals Limited
China
Product Name: Desogestrel
Price: $200.0/100mg $400.0/250mg $800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Desogestrel
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Desogestrel
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Desogestrel
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $86/10mM*1mLinDMSO

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Desogestrel

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