Sesamol structure
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Common Name | Sesamol | ||
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CAS Number | 533-31-3 | Molecular Weight | 138.121 | |
Density | 1.4±0.1 g/cm3 | Boiling Point | 274.0±29.0 °C at 760 mmHg | |
Molecular Formula | C7H6O3 | Melting Point | 62-65 °C(lit.) | |
MSDS | Chinese USA | Flash Point | 119.5±24.3 °C | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of SesamolSesamol is a constituent of sesame oil. Sesamol shows a free radical scavenging activity. Sesamol shows an IC50=5.95±0.56 μg/mL in the DPPH assay. Anti-oxidant activities[1]. Anticancer activities[2]. |
Name | 1,3-benzodioxol-5-ol |
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Synonym | More Synonyms |
Description | Sesamol is a constituent of sesame oil. Sesamol shows a free radical scavenging activity. Sesamol shows an IC50=5.95±0.56 μg/mL in the DPPH assay. Anti-oxidant activities[1]. Anticancer activities[2]. |
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Related Catalog | |
In Vitro | Sesamol has also been shown to be a classical inhibitor of lipid peroxidation[1]. Sesamol (0-1 mM) efficiently induces the apoptosis of human liver hepatocellular carcinoma (HepG2) cells. Sesamol suppresses cell proliferation and induces intrinsic and extrinsic apoptosis in HepG2 cells. Sesamol treatment elicites mitochondrial dysfunction by inducing a loss of mitochondrial membrane potential. Sesamol inhibits mitophagy and autophagy through impeding the PI3K Class III/Belin-1 pathway. Sesamol decreases the expression of anti-apoptotic protein Bcl-2, but shows no effect on the expression of apoptotic signal Bax. Sesamol improves the protein expression of Fas/FasL, and activates tBid and caspase-8 which are all involved in the extrinsic apoptosis pathway[2]. |
In Vivo | Sesamol treatment for 35 days does not significantly impact body weight, although the tumor volume is dramatically inhibited (40.56% size inhibitory rate with Sesamol at 200 mg/kg compared to the control group). However, a lower dose (100 mg/kg Sesamol) only has significant anti-tumor growth effect up to 27 days after the first treatment. The Bcl-2/Bax ratio in tumor tissues is also decreased. Moreover, in the Sesamol treatment group, levels of the cell proliferation marker Ki76 are down-regulated, and levels of the cell apoptosis marker cleaved-caspase 3 are increased when compared to control. The expression of LC3 protein is remarkably decreased by Sesamol in a dose-dependent manner[2] |
References |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 274.0±29.0 °C at 760 mmHg |
Melting Point | 62-65 °C(lit.) |
Molecular Formula | C7H6O3 |
Molecular Weight | 138.121 |
Flash Point | 119.5±24.3 °C |
Exact Mass | 138.031693 |
PSA | 38.69000 |
LogP | 1.52 |
Vapour Pressure | 0.0±0.6 mmHg at 25°C |
Index of Refraction | 1.609 |
Storage condition | −20°C |
Water Solubility | slightly soluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi:Irritant |
Risk Phrases | R36/37/38 |
Safety Phrases | S26-S36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | SM0890000 |
HS Code | 2932999099 |
Precursor 9 | |
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DownStream 10 | |
HS Code | 2932999099 |
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Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Synthesis and photopolymerization kinetics of benzophenone sesamol one-component photoinitiator.
Photochem. Photobiol. Sci. 12(2) , 323-9, (2013) A benzodioxole derivative, 4-(2-(benzodioxol-5-yloxy)ethoxy)benzophenone (BPC2BDO), based on 4-hydroxybenzophenone and sesamol was synthesized, and used as a one-component Type II photoinitiator. The ... |
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Comparison of the simple cyclic voltammetry (CV) and DPPH assays for the determination of antioxidant capacity of active principles.
Molecules 17(5) , 5126-38, (2012) Antioxidant activity of a number of small (low molecular weight) natural compounds found in spices, condiments or drugs (gallic acid, sesamol, eugenol, thymol, carvacrol, vanillin, salicylaldehyde, li... |
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The interaction of sesamol with DNA and cytotoxicity, apoptosis, and localization in HepG2 cells.
Food Chem. 141(1) , 289-96, (2013) Sesamol, a nutritional antioxidant phenolic compound present in sesame seed, has a potential therapeutic molecule effect against cancers. In this study, the interaction between sesamol and DNA was inv... |
5-Benzodioxolol |
MFCD00005827 |
5-Hydroxy-1,3-benzodioxole |
EINECS 208-561-5 |
Phenol, 3,4- (methylenedioxy)- |
Sesamol |
4,5-methylenedioxyphenol |
3,4-Methylenedioxyphenol |
1-hydroxy-3,4-methylenedioxybenzene |
4-hydroxy-1,2-methylenedioxy-benzene |
5-hydroxy-1,3-benzodioxolane |
3,4-(Methylenedioxy)phenol |
Methylene ether of oxyhydroquinone |
1,3-benzodioxol-5-ol |