Tetraethylene glycol monohexadecyl ether

Modify Date: 2025-08-25 09:30:25

Tetraethylene glycol monohexadecyl ether Structure
Tetraethylene glycol monohexadecyl ether structure
Common Name Tetraethylene glycol monohexadecyl ether
CAS Number 5274-63-5 Molecular Weight 418.65100
Density N/A Boiling Point N/A
Molecular Formula C24H50O5 Melting Point 37-38ºC
MSDS N/A Flash Point N/A

 Use of Tetraethylene glycol monohexadecyl ether


Tetraethylene glycol monohexadecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethanol
Synonym More Synonyms

 Tetraethylene glycol monohexadecyl ether Biological Activity

Description Tetraethylene glycol monohexadecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Melting Point 37-38ºC
Molecular Formula C24H50O5
Molecular Weight 418.65100
Exact Mass 418.36600
PSA 57.15000
LogP 5.52640
InChIKey CACXEVGZNASLOU-UHFFFAOYSA-N
SMILES CCCCCCCCCCCCCCCCOCCOCCOCCOCCO

 Safety Information

Safety Phrases 22-24/25
WGK Germany 3
HS Code 2909499000

 Customs

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

 Synonyms

CETETH-4
Tetraethylene glycol monohexadecyl ether
Hexadecyltetraglycol
C16E4
C16E4,Hexadecyl tetraethylene glycol ether,Hexadecyltetraglycol
polyoxyethylene 4 cetyl ether
Hexadecyl tetraethylene glycol ether
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