Tetraethylene glycol monohexadecyl ether

Names

[ Name ]:
Tetraethylene glycol monohexadecyl ether

[Synonym ]:
CETETH-4
Tetraethylene glycol monohexadecyl ether
Hexadecyltetraglycol
C16E4
C16E4,Hexadecyl tetraethylene glycol ether,Hexadecyltetraglycol
polyoxyethylene 4 cetyl ether
Hexadecyl tetraethylene glycol ether

Biological Activity

[Description]:

Tetraethylene glycol monohexadecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Melting Point ]:
37-38ºC

[ Molecular Formula ]:
C₂₄H₅₀O₅

[ Molecular Weight ]:
418.65100

[ Exact Mass ]:
418.36600

[ PSA ]:
57.15000

[ LogP ]:
5.52640

Safety Information

[ Safety Phrases ]:
22-24/25

[ WGK Germany ]:
3

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%