2-Nitroimidazole

Modify Date: 2024-01-02 15:09:39

2-Nitroimidazole structure	Common Name	2-Nitroimidazole
	CAS Number	527-73-1	Molecular Weight	113.075
	Density	1.6±0.1 g/cm3	Boiling Point	373.6±25.0 °C at 760 mmHg
	Molecular Formula	C₃H₃N₃O₂	Melting Point	287 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	179.7±23.2 °C
	Symbol	GHS07	Signal Word	Warning

Use of 2-Nitroimidazole

Azomycin is an antibiotic which can be active against aerobic Gram-positive and Gram-negative bacteria.

Name	2-nitroimidazole
Synonym	More Synonyms

Description	Azomycin is an antibiotic which can be active against aerobic Gram-positive and Gram-negative bacteria.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
Target	Bacterial[1]
In Vitro	Azomycin is an antibiotic which can be active against aerobic Gram-positive and Gram-negative bacteria. It is found that Azomycin is also active against a variety of anaerobic bacteria[1].
References	[1]. Shoji JH, et al. Isolation of azomycin from Pseudomonas fluorescens. J Antibiot (Tokyo). 1989 Oct;42(10):1513-4.

Density	1.6±0.1 g/cm3
Boiling Point	373.6±25.0 °C at 760 mmHg
Melting Point	287 °C (dec.)(lit.)
Molecular Formula	C₃H₃N₃O₂
Molecular Weight	113.075
Flash Point	179.7±23.2 °C
Exact Mass	113.022530
PSA	74.50000
LogP	0.15
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.612
Storage condition	Refrigerator
Water Solubility	insoluble

2-Nitroimidazole MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI7875000

CHEMICAL NAME :: Imidazole, 2-nitro-

CAS REGISTRY NUMBER :: 527-73-1

BEILSTEIN REFERENCE NO. :: 0116444

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C3-H3-N3-O2

MOLECULAR WEIGHT :: 113.09

WISWESSER LINE NOTATION :: T5M CNJ BNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 1 mg/plate

REFERENCE :: JGAMA9 Journal of General and Applied Microbiology. (Microbiology Research Foundation, c/o Japan Academic Soc. Center Bldg., 2-4-16 Yayoi, Bunkyo-ku, Tokyo, 113, Japan) V.1- 1955- Volume(issue)/page/year: 11,129,1965 *** REVIEWS *** TOXICOLOGY REVIEW ADCMAZ Advances in Chemotherapy. (New York, NY) V.1-3, 1964-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 3,39,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6614 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1822 (estimated) No. of Female Employees: 272 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	NI7875000
Packaging Group	III
Hazard Class	6.1
HS Code	2933990090

imidazol-2-ylam...

CAS#:42383-61-9

~66%

2-Nitroimidazole

CAS#:527-73-1

Literature: Yap, Suwan; Woodman, Owen L.; Crack, Peter J.; Williams, Spencer J. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 17 p. 5102 - 5106

2-Aminoimidazole

CAS#:7720-39-0

2-Nitroimidazole

CAS#:527-73-1

Literature: Luijten, W. C. M. M.; Thuijl, J. van Organic Mass Spectrometry, 1982 , vol. 17, # 7 p. 299 - 303

1-Trityl-1H-imi...

CAS#:15469-97-3

2-Nitroimidazole

CAS#:527-73-1

Literature: Davis, Dwight P.; Kirk, Kenneth L.; Cohen, Louis A. Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 253 - 256

Precursor 3
CAS#:42383-61-9 imidazol-2-ylam... CAS#:7720-39-0 2-Aminoimidazole CAS#:15469-97-3 1-Trityl-1H-imi...
DownStream 10
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CAS#:129449-06-5 3-(2-hydroxy-3-... CAS#:150196-34-2 1-(2'-NITRO-1'-... CAS#:13551-89-8 1H-Imidazole-1-... CAS#:137046-51-6 7-(4'-(2-nitroi...
CAS#:13551-86-5 α-Chloromethyl-... CAS#:1671-82-5 1H-Imidazole,1-...

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

A (99m)Tc-labeled misonidazole analogue: step toward a (99m)Tc-alternative to [18F]fluromisonidazole for detecting tumor hypoxia.

Cancer Biother. Radiopharm. 30(2) , 79-86, (2015)

The PET radiopharmaceutical [(18)F]Fluromisonidazole ([(18)F]FMISO) is presently the agent of choice for the clinical imaging of tumor hypoxia. Considering the logistic advantages of (99m)Tc and wider...

The synthesis and radiolabeling of 2-nitroimidazole derivatives of cyclam and their preclinical evaluation as positive markers of tumor hypoxia.

J. Nucl. Med. 43(6) , 837-50, (2002)

The cyclam ligand (1,4,8,11-tetraazacyclotetradecane) was condensed with various azomycin-containing synthons to produce chemical compounds that could chelate radioactive metals. It was expected that ...

The oxygen dependence of the reduction of nitroimidazoles in a radiolytic model system.

Int. J. Radiat. Oncol. Biol. Phys. 10(8) , 1323-6, (1984)

Radiation chemical reductions using eaq- and CO2- have been carried out in the presence of oxygen with metronidazole, p-nitroacetophenone, misonidazole and three other 2-nitroimidazoles. Low concentra...

2-Nitroimidazol

Azomycin

2-Nitro-1H-imidazole

MFCD00005185

2-Nitroimidazole

EINECS 208-425-5

1H-Imidazole, 2-nitro-

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2-Nitroimidazole
Price: ￥398.0/5g ￥148.0/1g
Purity: 97.0%
Stocking Period: Inquiry
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DC Chemicals Limited
China
Product Name: Azomycin (2-Nitroimidazole)
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Nitroimidazole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 2-Nitroimidazole
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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2-Nitroimidazole

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