Mebendazole-amine

Modify Date: 2024-01-09 22:45:06

Mebendazole-amine structure	Common Name	Mebendazole-amine
	CAS Number	52329-60-9	Molecular Weight	237.25700
	Density	1.351g/cm3	Boiling Point	504.5ºC at 760 mmHg
	Molecular Formula	C₁₄H₁₁N₃O	Melting Point	176-185°C
	MSDS	Chinese USA	Flash Point	258.9ºC
	Symbol	GHS07	Signal Word	Warning

Use of Mebendazole-amine

Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic drug[1].

Name	(2-amino-3H-benzimidazol-5-yl)-phenylmethanone
Synonym	More Synonyms

Description	Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic drug[1].
Related Catalog	Research Areas >> Others
References	[1]. Majewsky M, et al. Systematic identification of suspected anthelmintic benzimidazole metabolites using LC-MS/MS. J Pharm Biomed Anal. 2018;151:151-158. [2]. Pantziarka P, et al. Repurposing Drugs in Oncology (ReDO)-mebendazole as an anti-cancer agent. Ecancermedicalscience. 2014;8:443. Published 2014 Jul 10.

Description

Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic drug[1].

Related Catalog

Research Areas >> Others

References

[1]. Majewsky M, et al. Systematic identification of suspected anthelmintic benzimidazole metabolites using LC-MS/MS. J Pharm Biomed Anal. 2018;151:151-158.

[2]. Pantziarka P, et al. Repurposing Drugs in Oncology (ReDO)-mebendazole as an anti-cancer agent. Ecancermedicalscience. 2014;8:443. Published 2014 Jul 10.

Density	1.351g/cm3
Boiling Point	504.5ºC at 760 mmHg
Melting Point	176-185°C
Molecular Formula	C₁₄H₁₁N₃O
Molecular Weight	237.25700
Flash Point	258.9ºC
Exact Mass	237.09000
PSA	72.50000
LogP	2.30620
Index of Refraction	1.738
Storage condition	-20°C Freezer, Under Inert Atmosphere

Mebendazole-amine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OB1085000

CHEMICAL NAME :: Ketone, 2-amino-6-benzimidazolyl phenyl

CAS REGISTRY NUMBER :: 52329-60-9

LAST UPDATED :: 199307

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H11-N3-O

MOLECULAR WEIGHT :: 237.28

WISWESSER LINE NOTATION :: T56 BM DNJ CZ GVR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPPBAB Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1932- Volume(issue)/page/year: 48(4),29,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 257 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPPBAB Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1932- Volume(issue)/page/year: 48(4),29,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 755 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 31,505,1976

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xn
Risk Phrases	22
RIDADR	NONH for all modes of transport
RTECS	OB1085000
HS Code	2933990090

Precursor 0
DownStream 5
CAS#:104663-13-0 methyl 2-amino-... CAS#:31431-39-7 Mebendazole CAS#:75501-05-2 2-Amino-5(6)-[α... CAS#:89597-93-3 1-(6-benzoyl-1H...
CAS#:63197-61-5 2-amino-6-benzo...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Ketone,2-amino-5-benzimidazolyl phenyl

G-1029

Benzimidazole,2-amino-5-benzoyl

2-Amino-5-benzoyl-1H-benzimidazole

2-Amino-5-benzoylbenzimidazole

KETONE,2-AMINO-6-BENZIMIDAZOLYL PHENYL

DC Chemicals Limited
China
Product Name: R-18986
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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