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52329-60-9

52329-60-9 structure

52329-60-9 structure

Name: Mebendazole-amine
Chemical Name: (2-amino-3H-benzimidazol-5-yl)-phenylmethanone
CAS Number: 52329-60-9
Molecular Formula: C₁₄H₁₁N₃O
Molecular Weight: 237.25700
Catalog: analytical chemistry Standard Analytical standard
Create Date: 2018-12-28 21:25:27
Modify Date: 2024-01-09 22:45:06
Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic drug[1].

Name	(2-amino-3H-benzimidazol-5-yl)-phenylmethanone
Synonyms	Ketone,2-amino-5-benzimidazolyl phenyl G-1029 Benzimidazole,2-amino-5-benzoyl 2-Amino-5-benzoyl-1H-benzimidazole 2-Amino-5-benzoylbenzimidazole KETONE,2-AMINO-6-BENZIMIDAZOLYL PHENYL

Description	Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic drug[1].
Related Catalog	Research Areas >> Others
References	[1]. Majewsky M, et al. Systematic identification of suspected anthelmintic benzimidazole metabolites using LC-MS/MS. J Pharm Biomed Anal. 2018;151:151-158. [2]. Pantziarka P, et al. Repurposing Drugs in Oncology (ReDO)-mebendazole as an anti-cancer agent. Ecancermedicalscience. 2014;8:443. Published 2014 Jul 10.

Density	1.351g/cm3
Boiling Point	504.5ºC at 760 mmHg
Melting Point	176-185°C
Molecular Formula	C₁₄H₁₁N₃O
Molecular Weight	237.25700
Flash Point	258.9ºC
Exact Mass	237.09000
PSA	72.50000
LogP	2.30620
Index of Refraction	1.738
Storage condition	-20°C Freezer, Under Inert Atmosphere

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OB1085000

CHEMICAL NAME :: Ketone, 2-amino-6-benzimidazolyl phenyl

CAS REGISTRY NUMBER :: 52329-60-9

LAST UPDATED :: 199307

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H11-N3-O

MOLECULAR WEIGHT :: 237.28

WISWESSER LINE NOTATION :: T56 BM DNJ CZ GVR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPPBAB Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1932- Volume(issue)/page/year: 48(4),29,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 257 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPPBAB Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1932- Volume(issue)/page/year: 48(4),29,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 755 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 31,505,1976

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xn
Risk Phrases	22
RIDADR	NONH for all modes of transport
RTECS	OB1085000
HS Code	2933990090

Precursor 0
DownStream 5
104663-13-0 31431-39-7 75501-05-2 89597-93-3
63197-61-5

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%