Anisatin

Modify Date: 2025-09-05 08:44:32

Anisatin structure	Common Name	Anisatin
	CAS Number	5230-87-5	Molecular Weight	328.31500
	Density	1.149g/cm3	Boiling Point	251.2ºC at 760 mmHg
	Molecular Formula	C₁₅H₂₀O₈	Melting Point	227-228ºC
	MSDS	Chinese USA	Flash Point	106.7ºC
	Symbol	GHS06	Signal Word	Danger

Use of Anisatin

Anisatin, a pure toxic substance isolated from the seeds of a Japanese plant (Illicium anisatum) acts as a picrotoxin-like, non-competitive GABA antagonist. Anisatin suppresses GABA-induced currents in a concentration-dependent manner with an EC50 of ~1.10 μM[1].

Name	anisatin
Synonym	More Synonyms

Description	Anisatin, a pure toxic substance isolated from the seeds of a Japanese plant (Illicium anisatum) acts as a picrotoxin-like, non-competitive GABA antagonist. Anisatin suppresses GABA-induced currents in a concentration-dependent manner with an EC50 of ~1.10 μM[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	Anisatin inhibits [3H]diazepam binding enhanced by either GABA or pentobarbital, without affecting the basal specific binding to rat brain membranes[1].
In Vivo	In mice, the LD50 reported for anisatin ranges from 0.76 to 1 mg/kg (po and ip)[1].
References	[1]. Ikeda T, et al. Anisatin modulation of the gamma-aminobutyric acid receptor-channel in rat dorsal root ganglion neurons. Br J Pharmacol. 1999;127(7):1567-1576. [2]. Bao X, et al. Bioavailability and Pharmacokinetics of Anisatin in Mouse Blood by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry. Biomed Res Int. 2020;2020:8835447. Published 2020 Dec 23.

Density	1.149g/cm3
Boiling Point	251.2ºC at 760 mmHg
Melting Point	227-228ºC
Molecular Formula	C₁₅H₂₀O₈
Molecular Weight	328.31500
Flash Point	106.7ºC
Exact Mass	328.11600
PSA	133.52000
Index of Refraction	1.486
Storage condition	?20°C

Anisatin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WH1314700

CHEMICAL NAME :: Spiro(6H-4,9a-methanocyclopent(d)oxocin-6,3'-oxetane) -2,2'(1H)-dione, 4a-beta,5,6a,7,8,9- hexahydro-5,9a-dimethyl-1-alpha,5-beta,6a-beta,7-beta -tetrahydroxy-

CAS REGISTRY NUMBER :: 5230-87-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H20-O8

MOLECULAR WEIGHT :: 328.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 44,1908,1996

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy) Skin and Appendages - hair

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 55,524,1959

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300 + H330
Precautionary Statements	P260-P264-P284-P301 + P310-P310
Hazard Codes	T+
Risk Phrases	26/28
Safety Phrases	26-36/37/39-45
RIDADR	UN 2811 6.1 / PGII
RTECS	WH1314700

Fruit of illicium anisatum L.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Anisatin
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Anisatin
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Get all suppliers and price by the below link:

Anisatin suppliers

Anisatin price

Anisatin

Use of Anisatin

Names

Anisatin Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.