Ethylhydrocupreine
Ethylhydrocupreine structure
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Common Name | Ethylhydrocupreine | ||
|---|---|---|---|---|
| CAS Number | 522-60-1 | Molecular Weight | 340.45900 | |
| Density | 1.18g/cm3 | Boiling Point | 508.7ºC at 760mmHg | |
| Molecular Formula | C21H28N2O2 | Melting Point | 123-128° when solvent-free | |
| MSDS | Chinese USA | Flash Point | 261.5ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of EthylhydrocupreineEthylhydrocupreine (Optochin) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist[1][2][3][4]. |
| Name | optochin |
|---|---|
| Synonym | More Synonyms |
| Description | Ethylhydrocupreine (Optochin) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist[1][2][3][4]. |
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| Related Catalog | |
| Target |
S. pneumoniae[1] IC50: 25.75 nM (Plasmodium falciparum)[3] ggTas2r1, ggTas2r2 and ggTas2r7[4] |
| In Vitro | The mutation rate to Ethylhydrocupreine (Optochin) resistance is estimated using fluctuation analysis in three capsulated S. pneumoniae strains (S. pneumoniae D39 NCTC 7466, S. pneumoniae R6 ATCC BAA-255 and S. pneumoniae ATCC 49619). The exposure to subinhibitory concentrations of penicillin increased the mutation rate (expressed as mutation per cell division) to Ethylhydrocupreine (Optochin) resistance between 2.1- and 3.1-fold for all three strains studied[2]. |
| In Vivo | The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs[1]. |
| References |
| Density | 1.18g/cm3 |
|---|---|
| Boiling Point | 508.7ºC at 760mmHg |
| Melting Point | 123-128° when solvent-free |
| Molecular Formula | C21H28N2O2 |
| Molecular Weight | 340.45900 |
| Flash Point | 261.5ºC |
| Exact Mass | 340.21500 |
| PSA | 45.59000 |
| LogP | 3.72520 |
| Index of Refraction | 1.618 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Identifying mutator phenotypes among fluoroquinolone-resistant strains of Streptococcus pneumoniae using fluctuation analysis.
Antimicrob. Agents Chemother. 51 , 3225-9, (2007) The occurrence of mutator phenotypes among laboratory-generated and clinical levofloxacin-resistant strains of Streptococcus pneumoniae was determined using fluctuation analysis. The in vitro selectio... |
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Genotypic identification of presumptive Streptococcus pneumoniae by PCR using four genes highly specific for S. pneumoniae.
J. Med. Microbiol. 55(Pt 6) , 709-14, (2006) It was previously reported that two oligonucleotide primer sets (spn9802 and spn9828) for discriminating Streptococcus pneumoniae from pneumococcus-like oral streptococcal isolates using PCR had been ... |
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Possible overestimation of penicillin resistant Streptococcus pneumoniae colonization rates due to misidentification of oropharyngeal streptococci.
Diagn. Microbiol. Infect. Dis. 42(4) , 263-8, (2002) Standard identification of Streptococcus pneumoniae by optochin and bile solubility testing can lead to ambiguous results for certain isolates. Newer bacteriologic identification techniques (e.g., DNA... |
| Optochine |
| hydrocupreineethylether |
| ETHYLHYDROCUPREINE |
| Hydrocupureine ethyl ether |
| Numoquine |
| Ethylhydrocuprein |
| numoquin |
| optoquine |