Ethylhydrocupreine hydrochloride
Modify Date: 2025-08-21 23:22:21
Ethylhydrocupreine hydrochloride structure
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Common Name | Ethylhydrocupreine hydrochloride | ||
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| CAS Number | 3413-58-9 | Molecular Weight | 376.92000 | |
| Density | N/A | Boiling Point | 508.7ºC at 760 mmHg | |
| Molecular Formula | C21H29ClN2O2 | Melting Point | 121-123ºC | |
| MSDS | USA | Flash Point | 261.5ºC | |
Use of Ethylhydrocupreine hydrochlorideEthylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist[1][2][3][4]. |
| Name | ethylhydrocupreine hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist[1][2][3][4]. |
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| Related Catalog | |
| Target |
S. pneumoniae[1] IC50: 25.75 nM (Plasmodium falciparum)[3] ggTas2r1, ggTas2r2 and ggTas2r7[4] |
| In Vitro | The mutation rate to Ethylhydrocupreine (Optochin) resistance is estimated using fluctuation analysis in three capsulated S. pneumoniae strains (S. pneumoniae D39 NCTC 7466, S. pneumoniae R6 ATCC BAA-255 and S. pneumoniae ATCC 49619). The exposure to subinhibitory concentrations of penicillin increased the mutation rate (expressed as mutation per cell division) to Ethylhydrocupreine (Optochin) resistance between 2.1- and 3.1-fold for all three strains studied[2]. |
| In Vivo | The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs[1]. |
| References |
| Boiling Point | 508.7ºC at 760 mmHg |
|---|---|
| Melting Point | 121-123ºC |
| Molecular Formula | C21H29ClN2O2 |
| Molecular Weight | 376.92000 |
| Flash Point | 261.5ºC |
| Exact Mass | 376.19200 |
| PSA | 45.59000 |
| LogP | 4.52720 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | S22;S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | MW6300000 |
| HS Code | 29392900 |
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Identifying mutator phenotypes among fluoroquinolone-resistant strains of Streptococcus pneumoniae using fluctuation analysis.
Antimicrob. Agents Chemother. 51 , 3225-9, (2007) The occurrence of mutator phenotypes among laboratory-generated and clinical levofloxacin-resistant strains of Streptococcus pneumoniae was determined using fluctuation analysis. The in vitro selectio... |
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Genotypic identification of presumptive Streptococcus pneumoniae by PCR using four genes highly specific for S. pneumoniae.
J. Med. Microbiol. 55(Pt 6) , 709-14, (2006) It was previously reported that two oligonucleotide primer sets (spn9802 and spn9828) for discriminating Streptococcus pneumoniae from pneumococcus-like oral streptococcal isolates using PCR had been ... |
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Possible overestimation of penicillin resistant Streptococcus pneumoniae colonization rates due to misidentification of oropharyngeal streptococci.
Diagn. Microbiol. Infect. Dis. 42(4) , 263-8, (2002) Standard identification of Streptococcus pneumoniae by optochin and bile solubility testing can lead to ambiguous results for certain isolates. Newer bacteriologic identification techniques (e.g., DNA... |
| numoquinhydrochloride |
| OPTICHIN HYDROCHLORIDE |
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| MFCD00135594 |
| EINECS 222-302-3 |
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| o-ethyl-hydrocupreinhydrochloride |
| hydrocupreine,ethylester,hydrochloride |
| OptochineHCl |
| optoquinhydrochloride |
| optochinhydrochloride |