Quercitrin

Modify Date: 2024-01-02 15:42:54

Quercitrin Structure
Quercitrin structure
 Common Name Quercitrin
CAS Number 522-12-3 Molecular Weight 448.377
Density 1.8±0.1 g/cm3 Boiling Point 814.0±65.0 °C at 760 mmHg
Molecular Formula C21H20O11 Melting Point 174-183ºC
MSDS Chinese USA Flash Point 288.3±27.8 °C

 Use of Quercitrin


Quercitrin is a natural compound found in Tartary buckwheat with a potential anti-inflammation effect that is used to treat heart and vascular conditions.IC50 value:Target:In vitro: There were significant increases in caspase-3 activity, loss of MMP, and increases in the apoptotic cell population in response to quercitrin in DLD-1 colon cancer cells in a time- and dose-dependent manner. [1] In vivo: ICR mice received CCl4 intraperitoneally with or without quercitrin co-administration for 4 weeks. Data showed that quercitrin significantly suppressed the elevation of reactive oxygen species (ROS) production and malondialdehyde (MDA) content, reduced tissue plasminogen activator (t-PA) activity, enhanced the antioxidant enzyme activities and abrogated cytochrome P450 2E1 (CYP2E1) induction in mouse brains. [2]

 Names

Name quercitrin
Synonym More Synonyms

 Quercitrin Biological Activity

Description Quercitrin is a natural compound found in Tartary buckwheat with a potential anti-inflammation effect that is used to treat heart and vascular conditions.IC50 value:Target:In vitro: There were significant increases in caspase-3 activity, loss of MMP, and increases in the apoptotic cell population in response to quercitrin in DLD-1 colon cancer cells in a time- and dose-dependent manner. [1] In vivo: ICR mice received CCl4 intraperitoneally with or without quercitrin co-administration for 4 weeks. Data showed that quercitrin significantly suppressed the elevation of reactive oxygen species (ROS) production and malondialdehyde (MDA) content, reduced tissue plasminogen activator (t-PA) activity, enhanced the antioxidant enzyme activities and abrogated cytochrome P450 2E1 (CYP2E1) induction in mouse brains. [2]
Related Catalog
References

[1]. Cincin ZB, et al. Apoptotic Effects of Quercitrin on DLD-1 Colon Cancer Cell Line. Pathol Oncol Res. 2015 Apr;21(2):333-8.

[2]. Ma JQ, et al. Quercitrin offers protection against brain injury in mice by inhibiting oxidative stress and inflammation. Food Funct. 2016 Jan 20;7(1):549-56.

[3]. Li W, et al. Quercitrin ameliorates the development of systemic lupus erythematosus-like disease in a chronic graft-versus-host murine model. Am J Physiol Renal Physiol. 2016 Feb 24:ajprenal.00249.2015.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 814.0±65.0 °C at 760 mmHg
Melting Point 174-183ºC
Molecular Formula C21H20O11
Molecular Weight 448.377
Flash Point 288.3±27.8 °C
Exact Mass 448.100555
PSA 190.28000
LogP 2.17
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.776
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UZ5950000
CHEMICAL NAME :
Quercitrin
CAS REGISTRY NUMBER :
522-12-3
BEILSTEIN REFERENCE NO. :
0068135
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C21-H20-O11
MOLECULAR WEIGHT :
448.41
WISWESSER LINE NOTATION :
T66 BO EVJ CR CQ DQ& GQ IQ DO- BT6OTJ CQ DQ EQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
166 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 54,297,1978

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UZ5950000

 Synthetic Route

2''-O-Galloylquercitrin structure

2''-O-Galloylqu...

CAS#:80229-08-9

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Quercitrin Structure

Quercitrin

CAS#:522-12-3
Literature: Isobe, Takahiko; Kanazawa, Keiji; Fujimura, Makoto; Noda, Yukinao Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 10 p. 3239

 Articles58

More Articles
Separation of the antioxidant compound quercitrin from Lindera obtusiloba Blume and its antimelanogenic effect on B16F10 melanoma cells.

Biosci. Biotechnol. Biochem. 77(1) , 58-64, (2013)

Considering the growing evidence of the presence of antioxidant compounds in plant extracts, the objectives of this study were to identify antioxidant compounds in Lindera obtusiloba Blume (Lauraceae)...
[Chemical constituents from Commelina communis].

Zhongguo Zhong Yao Za Zhi 38(19) , 3304-8, (2013)

To investigate the chemical constituents from Commelina communis, fifteen compounds were separated and purified by silica gel, Sephadex LH-20, and ODS column chromatography, and semi-preparative HPLC....
Analysis of different European hazelnut (Corylus avellana L.) cultivars: authentication, phenotypic features, and phenolic profiles.

J. Agric. Food Chem. 62(26) , 6236-46, (2014)

Hazelnuts exhibit functional properties due to their content in fatty acids and phenolic compounds that could positively affect human health. The food industry requires precise traits for morphologica...

 Synonyms

quercetin 3-O-α-L-rhamnopyranoside
quercetin-3-L-rhamnoside
3-O-α-rhamnosylquercetine
Quercetin 3-O-L-rhamnoside
Quercitroside
QUERCETIN 3-L-RHAMNOSIDE
EINECS 208-322-5
Thujin
3,3',4',5,7-Pentahydroxyflavone 3-(6-deoxy-a-L-mannopyranoside)
4H-1-Benzopyran-4-one, 3-((6-deoxy-α-L-mannopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-on
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-one
Quercetin 3-O-α-L-rhamnoside
2-(3,4-Dihydroxyphényl)-5,7-dihydroxy-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-méthyltétrahydro-2H-pyran-2-yl]oxy}-4H-chromén-4-one
Quercetin-3-O-α-L-rhamnopyranoside
3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-benzopyran-4-one
Quercimelin
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl-6-deoxy-α-L-mannopyranoside
Quercetin-3-rhamnoside
4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-
Quercetrin
FLAVIN
Quercetin-3-O-rhamnoside
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-α-L-mannopyranoside
usafcf-2
quercetin 3-O-rhamnoside
MFCD00016932
3-[(6-Deoxy-a-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
Quercitrin
quercetin 3-rhamnoside
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Related Compounds: More...
Quercitrin 2''-O-arabinoside
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3'-O-((6-(2-nitro-4-azidophenylamino)hexyl)carbamoyl)quercitrin
104317-56-8
Chemsrc provides Quercitrin(CAS#:522-12-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Quercitrin are included as well.>> amp version: Quercitrin

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