Methylmalonic acid

Modify Date: 2025-08-21 10:19:57

Methylmalonic acid Structure
Methylmalonic acid structure
 Common Name Methylmalonic acid
CAS Number 516-05-2 Molecular Weight 118.088
Density 1.45 Boiling Point 334.4±25.0 °C at 760 mmHg
Molecular Formula C4H6O4 Melting Point 129-136 ºC
MSDS Chinese USA Flash Point 170.2±19.7 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Methylmalonic acid


Methylmalonate is an indicator of Vitamin B-12 deficiency in cancer.

 Names

Name ethylmalonic acid
Synonym More Synonyms

 Methylmalonic acid Biological Activity

Description Methylmalonate is an indicator of Vitamin B-12 deficiency in cancer.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Vitamin B-12 is required for Methylmalonate (Methylmalonic acid; MMA) to be converted to succinyl-CoA, and in combination with folic acid, for homocysteine (HC) to be converted to methionine. Therefore, Methylmalonate is clearly more specific to vitamin B-12 deficiency compared to HC[1].
References

[1]. Vashi P, et al. Methylmalonic Acid and Homocysteine as Indicators of Vitamin B-12 Deficiency in Cancer. PLoS One. 2016 Jan 25;11(1):e0147843.

 Chemical & Physical Properties

Density 1.45
Boiling Point 334.4±25.0 °C at 760 mmHg
Melting Point 129-136 ºC
Molecular Formula C4H6O4
Molecular Weight 118.088
Flash Point 170.2±19.7 °C
Exact Mass 118.026611
PSA 74.60000
LogP -0.21
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.474
Storage condition ?20°C
Water Solubility soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OO1400000
CHEMICAL NAME :
Malonic acid, methyl-
CAS REGISTRY NUMBER :
516-05-2
BEILSTEIN REFERENCE NO. :
1756084
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C4-H6-O4
MOLECULAR WEIGHT :
118.10
WISWESSER LINE NOTATION :
QV1VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,222,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02314

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS OO1400000
HS Code 2917190090

 Synthetic Route

 Customs

HS Code 2917190090
Summary 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles90

More Articles
Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

 Synonyms

Methylmalonic acid
Propanedioic acid, 2-methyl-
Methylpropanedioic acid
EINECS 208-219-5
2-Methylmalonic acid
methyl-Propanedioic acid
2-Methylpropanedioic acid
MFCD00002656
methyl-Malonic acid
2-Methyl1-malonic acid
Methylmalonate
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Chemsrc provides Methylmalonic acid(CAS#:516-05-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Methylmalonic acid are included as well.>> amp version: Methylmalonic acid

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