Methylmalonic acid

Modify Date: 2025-08-21 10:19:57

Methylmalonic acid structure	Common Name	Methylmalonic acid
	CAS Number	516-05-2	Molecular Weight	118.088
	Density	1.45	Boiling Point	334.4±25.0 °C at 760 mmHg
	Molecular Formula	C₄H₆O₄	Melting Point	129-136 ºC
	MSDS	Chinese USA	Flash Point	170.2±19.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of Methylmalonic acid

Methylmalonate is an indicator of Vitamin B-12 deficiency in cancer.

Name	ethylmalonic acid
Synonym	More Synonyms

Description	Methylmalonate is an indicator of Vitamin B-12 deficiency in cancer.
Related Catalog	Natural Products >> Acids and Aldehydes Research Areas >> Cancer
Target	Human Endogenous Metabolite
In Vitro	Vitamin B-12 is required for Methylmalonate (Methylmalonic acid; MMA) to be converted to succinyl-CoA, and in combination with folic acid, for homocysteine (HC) to be converted to methionine. Therefore, Methylmalonate is clearly more specific to vitamin B-12 deficiency compared to HC[1].
References	[1]. Vashi P, et al. Methylmalonic Acid and Homocysteine as Indicators of Vitamin B-12 Deficiency in Cancer. PLoS One. 2016 Jan 25;11(1):e0147843.

Density	1.45
Boiling Point	334.4±25.0 °C at 760 mmHg
Melting Point	129-136 ºC
Molecular Formula	C₄H₆O₄
Molecular Weight	118.088
Flash Point	170.2±19.7 °C
Exact Mass	118.026611
PSA	74.60000
LogP	-0.21
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.474
Storage condition	?20°C
Water Solubility	soluble

Methylmalonic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO1400000

CHEMICAL NAME :: Malonic acid, methyl-

CAS REGISTRY NUMBER :: 516-05-2

BEILSTEIN REFERENCE NO. :: 1756084

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H6-O4

MOLECULAR WEIGHT :: 118.10

WISWESSER LINE NOTATION :: QV1VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,222,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02314

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	OO1400000
HS Code	2917190090

HS Code	2917190090
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

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China
Product Name: Methylmalonic acid
Price: ￥Inquiry/25kg
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Delivery: Inquiry
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Price: ￥550/10 mM * 1 mL in DMSO

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Methylmalonic acid

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