Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Methylmalonic acid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Methylmalonic acid
Price: ￥88.0/5g ￥228.0/25g ￥638.0/100g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Methylmalonic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

516-05-2

516-05-2 structure

516-05-2 structure

Name: Methylmalonic acid
Chemical Name: ethylmalonic acid
CAS Number: 516-05-2
Molecular Formula: C₄H₆O₄
Molecular Weight: 118.088
Catalog: Chemical reagent Organic reagent fatty acid
Create Date: 2018-08-16 15:57:45
Modify Date: 2025-08-21 10:19:57
Methylmalonate is an indicator of Vitamin B-12 deficiency in cancer.

Name	ethylmalonic acid
Synonyms	Methylmalonic acid Propanedioic acid, 2-methyl- Methylpropanedioic acid EINECS 208-219-5 2-Methylmalonic acid methyl-Propanedioic acid 2-Methylpropanedioic acid MFCD00002656 methyl-Malonic acid 2-Methyl1-malonic acid Methylmalonate

Description	Methylmalonate is an indicator of Vitamin B-12 deficiency in cancer.
Related Catalog	Natural Products >> Acids and Aldehydes Research Areas >> Cancer
Target	Human Endogenous Metabolite
In Vitro	Vitamin B-12 is required for Methylmalonate (Methylmalonic acid; MMA) to be converted to succinyl-CoA, and in combination with folic acid, for homocysteine (HC) to be converted to methionine. Therefore, Methylmalonate is clearly more specific to vitamin B-12 deficiency compared to HC[1].
References	[1]. Vashi P, et al. Methylmalonic Acid and Homocysteine as Indicators of Vitamin B-12 Deficiency in Cancer. PLoS One. 2016 Jan 25;11(1):e0147843.

Density	1.45
Boiling Point	334.4±25.0 °C at 760 mmHg
Melting Point	129-136 ºC
Molecular Formula	C₄H₆O₄
Molecular Weight	118.088
Flash Point	170.2±19.7 °C
Exact Mass	118.026611
PSA	74.60000
LogP	-0.21
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.474
Storage condition	?20°C
Water Solubility	soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO1400000

CHEMICAL NAME :: Malonic acid, methyl-

CAS REGISTRY NUMBER :: 516-05-2

BEILSTEIN REFERENCE NO. :: 1756084

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H6-O4

MOLECULAR WEIGHT :: 118.10

WISWESSER LINE NOTATION :: QV1VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,222,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02314

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	OO1400000
HS Code	2917190090

HS Code	2917190090
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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