9-cis-Retinal

Modify Date: 2025-08-25 17:51:17

9-cis-Retinal structure	Common Name	9-cis-Retinal
	CAS Number	514-85-2	Molecular Weight	284.436
	Density	0.9±0.1 g/cm3	Boiling Point	421.4±14.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₈O	Melting Point	56-58ºC(lit.)
	MSDS	USA	Flash Point	205.4±12.4 °C
	Symbol	GHS07	Signal Word	Warning

Use of 9-cis-Retinal

9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II with Kds of 8 nM and 5 nM, respectively. 9-cis-Retinal expedites differentiation and maturation of rod photoreceptors in retinal organoids[1][2][3].

Name	9-cis-retinal
Synonym	More Synonyms

Description	9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II with Kds of 8 nM and 5 nM, respectively. 9-cis-Retinal expedites differentiation and maturation of rod photoreceptors in retinal organoids[1][2][3].
Related Catalog	Research Areas >> Others
Target	Human Endogenous Metabolite
In Vitro	The addition of 9-cis-Retinal, instead of the widely used all-trans retinoic acid, accelerates rod photoreceptor differentiation in organoid cultures, with higher rhodopsin expression and more mature mitochondrial morphology evident by day. 9-cis-Retinal can bind opsin to form functioning rhodopsin[3].
In Vivo	Treatment with 9-cis-retinal produced a significant recovery of the cone response in interphotoreceptor retinoid-binding protein (IRBP)-/- mice and shows that retinoid deficiency underlies cone dysfunction[4].
References	[1]. Kane MA, et al. Binding affinities of CRBPI and CRBPII for 9-cis-retinoids.Biochim Biophys Acta. 2011 May;1810(5):514-8. [2]. Mertz JR, et al. Identification and characterization of a stereospecific human enzyme that catalyzes 9-cis-retinol oxidation. A possible role in 9-cis-retinoic acid formation. J Biol Chem. 1997 May 2;272(18):11744-9. [3]. Kaya KD, et al. Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9-cis retinal. Mol Vis. 2019 Nov 11;25:663-678. [4]. Parker RO, et al. Normal cone function requires the interphotoreceptor retinoid binding protein. J Neurosci. 2009 Apr 8;29(14):4616-21.

Density	0.9±0.1 g/cm3
Boiling Point	421.4±14.0 °C at 760 mmHg
Melting Point	56-58ºC(lit.)
Molecular Formula	C₂₀H₂₈O
Molecular Weight	284.436
Flash Point	205.4±12.4 °C
Exact Mass	284.214020
PSA	17.07000
LogP	6.54
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.541
Storage condition	-20°C

9-cis-Retinal MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VH6406500

CHEMICAL NAME :: Retinal, 9-cis-

CAS REGISTRY NUMBER :: 514-85-2

BEILSTEIN REFERENCE NO. :: 1914180

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H28-O

MOLECULAR WEIGHT :: 284.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 25 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 83,563,1986

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H315-H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	20/21/22-38
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	VH6406500
HS Code	2912299000

Precursor 9
CAS#:116-31-4 All-trans-retinal CAS#:68-26-8 Vitamin A CAS#:58526-50-4 9-CIS-RETINOIC ... CAS#:54340-95-3 4,4-diethoxy-2-...
CAS#:145572-38-9 1,2-dibromo-4,4... CAS#:564-87-4 11-cis Retinal CAS#:127-47-9 Retinyl acetate CAS#:25529-00-4 6-methyl-8t-(2,...
CAS#:36678-63-4 magnesium,ethyn...
DownStream 4
CAS#:472-86-6 Retinal, 13-cis- CAS#:116-31-4 All-trans-retinal CAS#:564-87-4 11-cis Retinal CAS#:68-26-8 Vitamin A

HS Code	2912299000
Summary	2912299000. other cyclic aldehydes without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation.

Invest. Ophthalmol. Vis. Sci. 56 , 2553-67, (2015)

Inherent instability of the P23H mutant opsin accounts for approximately 10% of autosomal dominant retinitis pigmentosa cases. Our purpose was to develop an overall set of reliable screening strategie...

Cubozoan genome illuminates functional diversification of opsins and photoreceptor evolution.

Sci. Rep. 5 , 11885, (2015)

Animals sense light primarily by an opsin-based photopigment present in a photoreceptor cell. Cnidaria are arguably the most basal phylum containing a well-developed visual system. The evolutionary hi...

Constitutive phospholipid scramblase activity of a G protein-coupled receptor.

Nat. Commun. 5 , 5115, (2014)

Opsin, the rhodopsin apoprotein, was recently shown to be an ATP-independent flippase (or scramblase) that equilibrates phospholipids across photoreceptor disc membranes in mammalian retina, a process...

(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal

Retinal, all-trans-

all-trans-Retinene

9-cis-Vitamin A aldehyde

Retinal,9-cis

Isoretinene A

all-trans-retinal

all-trans-Vitamin A aldehyde

9-cis-Retinal

9-C-Retinal

Retinal, (9cis)-

all-trans-retinaldehyde

EINECS 208-188-8

(9cis)-Retinal

9-cis-7,11,13-trans retinal

11-cis-retinal

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 9-cis-Retinal
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: 9-cis-Retinal
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: 9-cis-Retinal
Price: $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 9-cis-retinal
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

9-cis-Retinal suppliers

Price: ￥2300/1 mg

Reference only. check more 9-cis-Retinal price

9-cis-Retinal

Use of 9-cis-Retinal

Names

9-cis-Retinal Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles36

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.