Isojacareubin

Modify Date: 2024-01-09 12:09:38

Isojacareubin structure	Common Name	Isojacareubin
	CAS Number	50597-93-8	Molecular Weight	326.30
	Density	1.5±0.1 g/cm3	Boiling Point	576.8±50.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₁₄O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	216.0±23.6 °C

Use of Isojacareubin

Isojacareubin can be isolated from Hypericum japonicum. Isojacareubin covalently inhibits SARS-CoV-2 3CLpro. Isojacareubin also has anti-helicobacter activity. Isojacareubin inhibits PKC, and suppresses hepatocellular carcinoma metastasis and induces apoptosis[1][2][3].

Name	6,10,11-trihydroxy-3,3-dimethyl-3H,7H-pyrano[2,3-c]xanthen-7-one
Synonym	More Synonyms

Description	Isojacareubin can be isolated from Hypericum japonicum. Isojacareubin covalently inhibits SARS-CoV-2 3CLpro. Isojacareubin also has anti-helicobacter activity. Isojacareubin inhibits PKC, and suppresses hepatocellular carcinoma metastasis and induces apoptosis[1][2][3].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Anti-infection >> SARS-CoV Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Kyoko Ishiguro, et al. An isopentenylated flavonol from Hypericum japonicum. Phytochemistry. 1993. 32 (6), 1583-1585. [2]. Khan A, et al. Discovery of Isojacareubin as a covalent inhibitor of SARS-CoV-2 main protease using structural and experimental approaches. J Med Virol. 2023 Feb;95(2):e28542. [3]. Yuan X, et al. Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo. Sci Rep. 2015 Aug 6;5:12889.

Description

Related Catalog

Signaling Pathways >> Epigenetics >> PKC

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Anti-infection >> SARS-CoV

Signaling Pathways >> TGF-beta/Smad >> PKC

Signaling Pathways >> Anti-infection >> Bacterial

References

[1]. Kyoko Ishiguro, et al. An isopentenylated flavonol from Hypericum japonicum. Phytochemistry. 1993. 32 (6), 1583-1585.

[2]. Khan A, et al. Discovery of Isojacareubin as a covalent inhibitor of SARS-CoV-2 main protease using structural and experimental approaches. J Med Virol. 2023 Feb;95(2):e28542.

[3]. Yuan X, et al. Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo. Sci Rep. 2015 Aug 6;5:12889.

Density	1.5±0.1 g/cm3
Boiling Point	576.8±50.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₄O₆
Molecular Weight	326.30
Flash Point	216.0±23.6 °C
Exact Mass	326.079041
PSA	100.13000
LogP	3.31
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.694

Hazard Codes	Xi

6,10,11-Trihydroxy-3,3-dimethyl-3H,7H-pyrano[2,3-c]xanthen-7-one

3H,7H-Pyrano[2,3-c]xanthen-7-one, 6,10,11-trihydroxy-3,3-dimethyl-

BioBioPha
China
Product Name: Isojacareubin
Price: ￥3900.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Isojacareubin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Isojacareubin

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