IK1 inhibitor PA-6

Modify Date: 2025-08-25 10:14:41

IK1 inhibitor PA-6 structure	Common Name	IK1 inhibitor PA-6
	CAS Number	500715-03-7	Molecular Weight	492.61
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₃₂N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of IK1 inhibitor PA-6

IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3].

Name	IK1 inhibitor PA-6

Description	IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 12-15 nM (KIR2.x currents)[1].
References	[1]. Takanari H, et al. Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue. Cardiovasc Res. 2013 Jul 1;99(1):203-14. [2]. Ji Y, et al. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. Br J Pharmacol. 2017 Aug;174(15):2576-2590. [3]. Ji Y, et al. PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression. J Biomed Sci. 2017 Jul 15;24(1):44.

Molecular Formula	C₃₁H₃₂N₄O₂
Molecular Weight	492.61

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: IK1 inhibitor PA-6
Price: Check
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: IK1 inhibitor PA-6
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DC Chemicals Limited
China
Product Name: IK1 inhibitor PA-6
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.