IK1 inhibitor PA-6
Names
[ CAS No. ]:
500715-03-7
[ Name ]:
IK1 inhibitor PA-6
Biological Activity
[Description]:
IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3].
[Related Catalog]:
[Target]
IC50: 12-15 nM (KIR2.x currents)[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C31H32N4O2
[ Molecular Weight ]:
492.61
Related Compounds
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