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IRAK inhibitor 6

Names

[ CAS No. ]:
1042672-97-8

[ Name ]:
IRAK inhibitor 6

[Synonym ]:
4-Thiazolecarboxamide, N-[2-methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-
CS-0602
IRAK inhibitor 6
N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-1,3-thiazole-4-carboxamide
X6124
N-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-4-carboxamide

Biological Activity

[Description]:

IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor associated kinase 4 (IRAK-4) with IC50 of 160 nM.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> IRAK
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Research Areas >> Inflammation/Immunology

[Target]

IC50: 160 nM (IRAK-4)[1]


[In Vitro]

IRAK inhibitor 6 significantly improves potency against IRAK-4. Potency effects additive, IRAK inhibitor 6 is the most active compound among these compound tested[1].

[References]

[1]. Buckley G, et al. IRAK-4 inhibitors. Part 1: a series of amides. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3211-4.


[Related Small Molecules]

IRAK-1-4 Inhibitor I | PF06650833 | CA-4948 | ginsenoside Rb1 | IRAK4-IN-1 | IRAK inhibitor 1 | IRAK inhibitor 4 | IRAK inhibitor 2 | IRAK inhibitor 3

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C20H20N4O3S

[ Molecular Weight ]:
396.463

[ Exact Mass ]:
396.125610

[ PSA ]:
108.31000

[ LogP ]:
1.59

[ Index of Refraction ]:
1.652

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds