IRAK inhibitor 3
Names
[ CAS No. ]:
1012343-93-9
[ Name ]:
IRAK inhibitor 3
[Synonym ]:
IRAK inhibitor 3
4-((3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-ylamino)methyl)-benzenesulfonamide
CS-0605
Biological Activity
[Description]:
IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.
[Related Catalog]:
[Target]
IRAK[1]
[In Vitro]
IRAK inhibitor 3 is an IRAK modulator, which can be used for treating an inflammatory condition, cell proliferative disorder, immune disorder[1].
[Kinase Assay]
5 μL of a solution of IRAK inhibitor 3 at a concentration of 50 μM or less in 1% (v/v) DMSO is added to the wells of a 96-well area Black Polystyrene plates. The final concentrations in the reaction well are 10 μM ATP, 0.5 μM IRAK4 CH373, 1.6 μM IRAKI peptide, 1 mM MgCl2, 2 mM DTT, 5 mM MnCl2, 0.01 % BSA, and 0.01 % Tween-20. The volume of the reaction is 45 μL. The reaction mixture is incubated at room temperature for 30 minutes and stopped with the addition of 5 μL of 100 mM EDTA[1].
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Molecular Formula ]:
C21H21N5O4S
[ Molecular Weight ]:
439.48800
[ Exact Mass ]:
439.13100
[ PSA ]:
132.45000
[ LogP ]:
3.87600
[ Storage condition ]:
2-8℃