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PI3Kγ inhibitor 3

Names

[ CAS No. ]:
2132961-46-5

[ Name ]:
PI3Kγ inhibitor 3

Biological Activity

[Description]:

PI3Kγ inhibitor 3 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[Target]

PI3Kγ:9.1 (pIC50)

PI3Kα:5.1 (pIC50)

PI3Kβ:4.5 (pIC50)

PI3Kδ:6.5 (pIC50)

PI3KC2α:5 (pIC50)

PI3KC2β:7.5 (pIC50)

PI3KC2γ:5.5 (pIC50)

PI3KC3:5.1 (pIC50)


[In Vitro]

PI3Kγ inhibitor 3 (Compound 15) also inhibits PI3KC2α, PI3KC2β, PI3KC2γ, and PI3KC3 with pIC50s of <5, 7.5, 5.5, and 5.1, respectively[1].

[References]

[1]. Pemberton N, et al. Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors. J Med Chem. 2018 Jun 28;61(12):5435-5441.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H23N3O4S2

[ Molecular Weight ]:
433.54

Related Compounds