1042672-97-8
1042672-97-8 structure
- Name: IRAK inhibitor 6
- Chemical Name: N-(2-methoxy-4-morpholin-4-ylphenyl)-2-pyridin-3-yl-1,3-thiazole-4-carboxamide
- CAS Number: 1042672-97-8
- Molecular Formula: C20H20N4O3S
- Molecular Weight: 396.463
- Catalog: Signaling Pathways Immunology/Inflammation IRAK
- Create Date: 2016-12-29 03:41:59
- Modify Date: 2024-01-17 11:11:40
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IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor associated kinase 4 (IRAK-4) with IC50 of 160 nM.
| Name | N-(2-methoxy-4-morpholin-4-ylphenyl)-2-pyridin-3-yl-1,3-thiazole-4-carboxamide |
|---|---|
| Synonyms |
4-Thiazolecarboxamide, N-[2-methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-
CS-0602 IRAK inhibitor 6 N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-1,3-thiazole-4-carboxamide X6124 N-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-4-carboxamide |
| Description | IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor associated kinase 4 (IRAK-4) with IC50 of 160 nM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 160 nM (IRAK-4)[1] |
| In Vitro | IRAK inhibitor 6 significantly improves potency against IRAK-4. Potency effects additive, IRAK inhibitor 6 is the most active compound among these compound tested[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H20N4O3S |
| Molecular Weight | 396.463 |
| Exact Mass | 396.125610 |
| PSA | 108.31000 |
| LogP | 1.59 |
| Index of Refraction | 1.652 |
| Storage condition | 2-8℃ |
|
~%
1042672-97-8 |
| Literature: Buckley, George M.; Gowers, Lewis; Higueruelo, Alicia Perez; Jenkins, Kerry; Mack, Stephen R.; Morgan, Trevor; Parry, David M.; Pitt, William R.; Rausch, Oliver; Richard, Marianna D.; Sabin, Verity; Fraser, Joanne L. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3211 - 3214 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |