2-Oxo-2H-pyran-5-carboxylic acid

Modify Date: 2024-01-04 17:17:03

2-Oxo-2H-pyran-5-carboxylic acid Structure
2-Oxo-2H-pyran-5-carboxylic acid structure
Common Name 2-Oxo-2H-pyran-5-carboxylic acid
CAS Number 500-05-0 Molecular Weight 140.094
Density 1.5±0.1 g/cm3 Boiling Point 282.4±0.0 °C at 760 mmHg
Molecular Formula C6H4O4 Melting Point 203-205 °C (dec.)(lit.)
MSDS N/A Flash Point 137.3±19.4 °C

 Use of 2-Oxo-2H-pyran-5-carboxylic acid


Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavours, fragrances and cosmetics industries, as polymer components, and as pharmaceutical scaffolds displaying anti-bronchial and -malarial activity[1].

 Names

Name Coumalic acid
Synonym More Synonyms

 2-Oxo-2H-pyran-5-carboxylic acid Biological Activity

Description Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavours, fragrances and cosmetics industries, as polymer components, and as pharmaceutical scaffolds displaying anti-bronchial and -malarial activity[1].
Related Catalog
References

[1]. Smith LK, et, al. Flow synthesis of coumalic acid and its derivatization. Department of Chemistry. 2018, 3: 722-732.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 282.4±0.0 °C at 760 mmHg
Melting Point 203-205 °C (dec.)(lit.)
Molecular Formula C6H4O4
Molecular Weight 140.094
Flash Point 137.3±19.4 °C
Exact Mass 140.010956
PSA 67.51000
LogP -0.43
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.577

 Safety Information

Hazard Codes Xi
Safety Phrases S22-S24/25
WGK Germany 3

 Synthetic Route

~82%

2-Oxo-2H-pyran-5-carboxylic acid Structure

2-Oxo-2H-pyran-...

CAS#:500-05-0

Literature: Rosenmund, Peter; Casutt, Michael; Wittich, Michael Liebigs Annalen der Chemie, 1990 , p. 233 - 238

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2-Oxo-2H-pyran-5-carboxylic acid Structure

2-Oxo-2H-pyran-...

CAS#:500-05-0

Literature: Caldwell et al. Journal of the American Chemical Society, 1944 , vol. 66, p. 1479,1482

~%

2-Oxo-2H-pyran-5-carboxylic acid Structure

2-Oxo-2H-pyran-...

CAS#:500-05-0

Literature: v. Pechmann Justus Liebigs Annalen der Chemie, 1893 , vol. 273, p. 176

~%

2-Oxo-2H-pyran-5-carboxylic acid Structure

2-Oxo-2H-pyran-...

CAS#:500-05-0

Literature: v.Pechmann Chemische Berichte, 1884 , vol. 17, p. 936 Justus Liebigs Annalen der Chemie, 1891 , vol. 264, p. 262,272

~%

2-Oxo-2H-pyran-5-carboxylic acid Structure

2-Oxo-2H-pyran-...

CAS#:500-05-0

Literature: v.Pechmann Chemische Berichte, 1884 , vol. 17, p. 936 Justus Liebigs Annalen der Chemie, 1891 , vol. 264, p. 262,272

 Synonyms

2-Pyrone-5-carboxylic acid,2-Oxo-2H-pyran-5-carboxylic acid
2H-Pyran-5-carboxylic acid, 2-oxo-
6-oxopyran-3-carboxylic acid
α-Pyrone-5-carboxylic Acid
2-Oxo-2H-pyran-5-carboxylic acid
Cumalic Acid
Coumalic Acid
EINECS 207-899-0
MFCD00006644