Hinokitiol

Modify Date: 2024-01-02 18:01:01

Hinokitiol structure	Common Name	Hinokitiol
	CAS Number	499-44-5	Molecular Weight	164.201
	Density	1.1±0.1 g/cm3	Boiling Point	303.4±35.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₂O₂	Melting Point	50-52 °C(lit.)
	MSDS	Chinese USA	Flash Point	128.1±18.5 °C
	Symbol	GHS07	Signal Word	Warning

Use of Hinokitiol

Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

Name	β-thujaplicin
Synonym	More Synonyms

Description	Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.
Related Catalog	Signaling Pathways >> Epigenetics >> DNA Methyltransferase Signaling Pathways >> NF-κB >> Keap1-Nrf2 Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer Research Areas >> Infection
Target	DNMT1 Nrf2
In Vitro	In U87MG and T98G glioma cell lines, hinokitiol demonstrates a dose-dependent decrease in viability, with IC50 values of 316.5 ± 35.5 and 152.5 ± 25.3 µM, respectively. Hinokitiol represses ALDH activity and self-renewal ability in glioma stem cells, and inhibits in vitro oncogenicity. Hinokitiol also reduces Nrf2 expression in glioma stem cells in a dose-dependent manner[1]. Hinokitiol (0-100 μM) inhibits colon cancer cell growth in a dose- and time-dependent manner. Hinokitiol (5, 10 μM) decreases DNMT1 and UHRF1 mRNA and protein expression, and increases TET1 expression via enhancement of 5hmC level in HCT-116 cells. Furthermore, hinokitiol reduces methylation status and restores mRNA expression of MGMT, CHST10, and BTG4 genes[2].
Cell Assay	U87MG and T98G glioma cells are cultured in Dulbecco's modified Eagle's medium with Ham's F12 medium (DMEM/F-12) containing 10% fetal bovine serum. Cell viability is determined using MTT to evaluate the cytotoxicity of hinokitiol. Cells are seeded in 24-well plates (1×105 cells/well) in the presence of various concentration of hinokitiol or vehicle at 37°C for 24 h followed by incubation with MTT reagent. The blue formazan crystals of viable cells are dissolved in DMSO and then evaluated spectrophotometrically at 570 nm. DMSO-treated group is set as 100%, and data are presented as percentage of DMSO control. IC50 values are calculated by the GraFit software.
References	[1]. Ouyang WC, et al. Hinokitiol suppresses cancer stemness and oncogenicity in glioma stem cells by Nrf2 regulation. Cancer Chemother Pharmacol. 2017 Aug;80(2):411-419. [2]. Seo JS, et al. Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells. BMC Cell Biol. 2017 Feb 27;18(1):14.

Density	1.1±0.1 g/cm3
Boiling Point	303.4±35.0 °C at 760 mmHg
Melting Point	50-52 °C(lit.)
Molecular Formula	C₁₀H₁₂O₂
Molecular Weight	164.201
Flash Point	128.1±18.5 °C
Exact Mass	164.083725
PSA	37.30000
LogP	1.89
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.554

Hinokitiol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU4200000

CHEMICAL NAME :: 2,4,6-Cycloheptatrien-1-one, 2-hydroxy-4-isopropyl-

CAS REGISTRY NUMBER :: 499-44-5

BEILSTEIN REFERENCE NO. :: 2045206

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H12-O2

MOLECULAR WEIGHT :: 164.22

WISWESSER LINE NOTATION :: L7VJ BQ DY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Gastrointestinal - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570591

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 85 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,755,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 541 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 91,550,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 128 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 91,550,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570591

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 48,722,1959

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GU4200000
HS Code	2914400090

Precursor 8
CAS#:4570-11-0 2-hydroxy-6-pro... CAS#:310905-95-4 3-Cycloheptene-... CAS#:698-47-5 6-bromo-2-hydro... CAS#:55076-49-8 2,4,6-Cyclohept...
CAS#:108168-72-5 3-propan-2-ylcy... CAS#:1728-32-1 1,3,5-Cyclohept... CAS#:1714-40-5 3-Methoxycycloh... CAS#:133826-10-5 1,3-Cycloheptad...
DownStream 9
CAS#:931-88-4 Cyclooctene CAS#:499-44-5 Hinokitiol CAS#:142-29-0 Cyclopentene CAS#:79-31-2 Isobutyric acid
CAS#:88088-40-8 4-propan-2-ylcy... CAS#:90035-67-9 5-amino-2-hydro... CAS#:92832-19-4 2-phenylmethoxy... CAS#:54755-56-5 2,5-dihydroxy-6...
CAS#:55438-27-2 2-hydrazinyl-6-...

HS Code	2914400090
Summary	2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Determination of hinokitiol in skin lotion by high-performance liquid chromatography-ultraviolet detection after precolumn derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole.

J. Cosmet. Sci. 64(5) , 381-9, (2013)

Hinokitiol, a potent, broad-spectrum antibacterial agent, is a component of various personal care products. In this study, the concentration of hinokitiol in skin lotion was analyzed by means of high-...

The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs.

Org. Biomol. Chem. 10(43) , 8597-604, (2012)

A direct route to analogs of the naturally occurring tropolone β-thujaplicin has been developed in just four steps from furan. Using this method, a series of derivatives were synthesized and evaluated...

High-performance liquid chromatography with dual-wavelength ultraviolet detection for measurement of hinokitiol in personal care products.

J. Cosmet. Sci. 60(5) , 519-25, (2009)

Hinokitiol is found in the heartwood of several cupressaceous plants and is frequently added to cosmetic products such as hair restorers, skin lotions, and body soaps because of its potent and broad-s...

Isopropyltropolone

2-Hydroxy-6-(propan-2-yl)cyclohepta-2,4,6-trien-1-one

B-THUJAPLICIN

2,4,6-cycloheptatrien-1-one, 2-hydroxy-6-(1-methylethyl)-

2-Hydroxy-6-(propan-2-yl)cyclohepta-2,4,6-trien-1-on

beta-thujaplicin

4-ISOPROPYLTROPOLONE

MFCD00040180

2-Hydroxy-4-isopropylcyclohepta-2,4,6-trien-1-one

2,4,6-Cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)-

β-Thujaplicine

EINECS 207-880-7

Hinokitiol

β-Thujaplicin

Hinokitol

2-Hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one

2-hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Hinokitiol
Price: ￥1828.0/25g ￥658.0/100mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Hinokitiol
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Hinokitiol
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Hinokitiol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

Get all suppliers and price by the below link:

Hinokitiol suppliers

Price: $66/10mM*1mLinDMSO

Reference only. check more Hinokitiol price

Hinokitiol

Use of Hinokitiol

Names

Hinokitiol Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles32

Synonyms