6β-Naltrexol
6β-Naltrexol structure
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Common Name | 6β-Naltrexol | ||
|---|---|---|---|---|
| CAS Number | 49625-89-0 | Molecular Weight | 343.42 | |
| Density | 1.48g/cm3 | Boiling Point | 557.5ºC at 760mmHg | |
| Molecular Formula | C20H25NO4 | Melting Point | 90-96ºC | |
| MSDS | N/A | Flash Point | 291ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
Use of 6β-Naltrexol6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit[1]. |
| Name | 6β-Naltrexol |
|---|---|
| Synonym | More Synonyms |
| Description | 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit[1]. |
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| Related Catalog | |
| References |
| Density | 1.48g/cm3 |
|---|---|
| Boiling Point | 557.5ºC at 760mmHg |
| Melting Point | 90-96ºC |
| Molecular Formula | C20H25NO4 |
| Molecular Weight | 343.42 |
| Flash Point | 291ºC |
| Exact Mass | 343.17800 |
| PSA | 73.16000 |
| LogP | 1.25510 |
| Index of Refraction | 1.719 |
| InChIKey | JLVNEHKORQFVQJ-PYIJOLGTSA-N |
| SMILES | Oc1ccc2c3c1OC1C(O)CCC4(O)C(C2)N(CC2CC2)CCC314 |
| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
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Conformational analysis of 6α- and 6β-naltrexol and derivatives and relationship to opioid receptor affinity.
J. Chem. Inf. Model. 52(2) , 391-5, (2012) Naltrexol and its C₆ α and β desoxy, iodo, mesyl, tosyl, trifyl, dimethylcarbamyl, and diphenylcarbamyl derivatives were studied in their energy-minimized C ring chair-like and boat-like conformations... |
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In vivo evaluation of a transdermal codrug of 6-beta-naltrexol linked to hydroxybupropion in hairless guinea pigs.
Eur. J. Pharm. Sci. 33(4-5) , 371-9, (2008) 6-Beta-naltrexol is the major active metabolite of naltrexone, NTX, a potent mu-opioid receptor antagonist used in the treatment of alcohol dependence and opioid abuse. Compared to naloxone, NTX has a... |
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Comparison of naltrexone, 6alpha-naltrexol, and 6beta-naltrexol in morphine-dependent and in nondependent rhesus monkeys.
Psychopharmacology 195(4) , 479-86, (2008) Some opioid receptor ligands that appear to be neutral antagonists can have inverse agonist activity under conditions of increased constitutive activity (e.g., agonist treatment).This study compared t... |
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